{"id":"W4283712398","doi":"10.3389/fphar.2022.902259","title":"NEU1—A Unique Therapeutic Target for Alzheimer’s Disease","year":2022,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; University of Alberta","funders":"","keywords":"Neurodegeneration; Disease; Sialidase; Neuroscience; Immune system; Biology; Medicine; Bioinformatics; Immunology; Neuraminidase; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003665576,0.0007284061,0.0007955737,0.001444777,0.000274235,0.0007832253,0.0006709207,0.001098652,0.002697091],"category_scores_gemma":[0.0003228108,0.0002007745,0.0003221477,0.001118981,0.0003956729,0.001335725,0.0006498403,0.002467453,0.001845434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004806375,"about_ca_system_score_gemma":0.0006482064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006177441,"about_ca_topic_score_gemma":0.001284075,"domain_scores_codex":[0.9998964,0.00001824339,0.00001254156,0.00002179069,0.0000377094,0.00001342016],"domain_scores_gemma":[0.9999126,0.00002987965,0.00001139068,0.000003483961,0.00002833293,0.00001423981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001055759,0.0001122877,0.0001208692,0.009770993,0.00004949187,0.0003474318,0.00007004464,0.000322105,0.004655809,0.007602988,0.04816316,0.9286792],"study_design_scores_gemma":[0.00002009742,0.00009035704,0.0003345955,0.001145015,0.00004470324,0.001280374,0.00003224521,0.00008910705,0.0007952006,0.001842581,0.9943125,0.00001326474],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001991817,0.9972777,0.0001841768,0.0004182457,0.000460486,0.000004952034,0.00001651924,0.00001063156,0.00142809],"genre_scores_gemma":[0.00111493,0.9968478,0.0002385571,0.0003746387,0.0002696295,0.000008169694,0.0000358125,0.000002226465,0.0011082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002697091,"threshold_uncertainty_score":0.009022653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07021019332151715,"score_gpt":0.3983798017066508,"score_spread":0.3281696083851336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}