{"id":"W4283713497","doi":"10.1111/jdv.18376","title":"Comparative effectiveness of biologics in clinical practice: week 12 primary outcomes from an international observational <i>psoriasis study of health outcomes</i> (<scp>PSoHO</scp>)","year":2022,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"UCB Pharma; Sanofi Genzyme; LEO Pharma; Biogen; Celgene; Sanofi; Pfizer; Eli Lilly and Company","keywords":"Medicine; Secukinumab; Ustekinumab; Psoriasis; Ixekizumab; Psoriatic arthritis; Psoriasis Area and Severity Index; Observational study; Cohort; Clinical endpoint; Internal medicine; Dermatology Life Quality Index; Cohort study; Clinical trial; Physical therapy; Adalimumab; Dermatology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02414013,0.0007153794,0.001643608,0.001328132,0.0004157478,0.001260874,0.0009350788,0.001445633,0.003098981],"category_scores_gemma":[0.04441087,0.0003559917,0.003508431,0.001372898,0.000705881,0.001035288,0.001407405,0.001808076,0.0003543887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008114258,"about_ca_system_score_gemma":0.0009672444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001233785,"about_ca_topic_score_gemma":0.001095379,"domain_scores_codex":[0.9696289,0.02232901,0.002236421,0.002517078,0.002672411,0.0006160985],"domain_scores_gemma":[0.9498333,0.02590737,0.01623128,0.004207748,0.001784892,0.002035319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.495187,0.006981757,0.3978474,0.002177716,0.04165048,0.0001143168,0.00060581,0.005259382,0.001434218,0.000704636,0.002641176,0.04539608],"study_design_scores_gemma":[0.05981705,0.08452039,0.8146493,0.0005248183,0.02299757,0.0004658816,0.0004724486,0.00856499,0.002035443,0.001276432,0.004510719,0.0001650347],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882267,0.003320871,0.00131489,0.000279087,0.00007204058,0.0006624527,0.004036623,0.0000256361,0.002061568],"genre_scores_gemma":[0.9950154,0.0003998017,0.0009326711,0.0001619781,0.00005911744,0.0005940728,0.002578299,0.00001014192,0.0002484877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02414013,"threshold_uncertainty_score":0.1276667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1047750623908989,"score_gpt":0.3722308858027155,"score_spread":0.2674558234118166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}