{"id":"W4283713497","doi":"10.1111/jdv.18376","title":"Comparative effectiveness of biologics in clinical practice: week 12 primary outcomes from an international observational <i>psoriasis study of health outcomes</i> (<scp>PSoHO</scp>)","year":2022,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"UCB Pharma; Sanofi Genzyme; LEO Pharma; Biogen; Celgene; Sanofi; Pfizer; Eli Lilly and Company","keywords":"Medicine; Secukinumab; Ustekinumab; Psoriasis; Ixekizumab; Psoriatic arthritis; Psoriasis Area and Severity Index; Observational study; Cohort; Clinical endpoint; Internal medicine; Dermatology Life Quality Index; Cohort study; Clinical trial; Physical therapy; Adalimumab; Dermatology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003765991,0.0002189731,0.001563549,0.0002509672,0.0001550291,0.000002558023,0.0008013911,0.0001902855,0.00001830029],"category_scores_gemma":[0.0006867031,0.0001536766,0.0002395461,0.0001649414,0.0004818066,0.0001756051,0.0004668287,0.0008585646,0.0000017802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005099806,"about_ca_system_score_gemma":0.0001417143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004624626,"about_ca_topic_score_gemma":0.000008616271,"domain_scores_codex":[0.9790066,0.01844131,0.001915928,0.0002769136,0.000136023,0.0002231965],"domain_scores_gemma":[0.9912633,0.005357327,0.003045947,0.0001881926,0.0001116292,0.00003363697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009554849,0.003248083,0.9877506,0.00002270792,0.001859531,0.00002719884,0.001577654,0.0001284326,0.001638152,0.0005602738,0.0002168205,0.002015019],"study_design_scores_gemma":[0.006438029,0.0007345869,0.9867334,0.00002494588,0.000247322,0.0004581005,0.001795853,0.000002553998,0.0008607819,0.0004026593,0.002236569,0.00006516351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946853,0.001741988,0.00002236031,0.001506982,0.001294485,0.0003120025,0.0001186509,0.000006064706,0.0003121749],"genre_scores_gemma":[0.9986429,0.0002649894,0.0002746376,0.000688757,0.0000313888,0.000007057061,0.0000530529,0.00001228542,0.00002494893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01308399,"threshold_uncertainty_score":0.6266751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1047750623908989,"score_gpt":0.3722308858027155,"score_spread":0.2674558234118166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}