{"id":"W4283713624","doi":"10.1136/annrheumdis-2022-eular.1551","title":"AB0894 Efficacy and Safety of Guselkumab in Biologic-Naïve Patients With Active Axial Psoriatic Arthritis: Study Design of a Phase 4, Randomized, Double-Blind, Placebo-Controlled Trial","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"","keywords":"Medicine; Psoriatic arthritis; Double blind; Placebo; Placebo-controlled study; Randomized controlled trial; Dermatology; Arthritis; Internal medicine; Psoriasis; Physical therapy; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003158939,0.002312243,0.004770292,0.0007327683,0.0007058851,0.001347256,0.001482645,0.002722791,0.006955231],"category_scores_gemma":[0.002770055,0.001264679,0.002361162,0.0006995741,0.001771809,0.001875982,0.0005879065,0.003552151,0.001778108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007022085,"about_ca_system_score_gemma":0.001210244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005399177,"about_ca_topic_score_gemma":0.001024612,"domain_scores_codex":[0.9982914,0.001022926,0.0001240064,0.0002287438,0.0001234617,0.0002094999],"domain_scores_gemma":[0.9985684,0.0004714789,0.0002697412,0.0001404173,0.000117083,0.0004327522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9786159,0.007204978,0.000581577,0.000511363,0.0008524664,0.00003331011,0.00003497007,0.0002307935,0.002423802,0.00006541007,0.0003131367,0.009132191],"study_design_scores_gemma":[0.9485297,0.04939745,0.0009949803,0.00001662078,0.0003628203,0.00001657659,0.00000991852,0.0001720035,0.0001832227,0.00006412462,0.0002405243,0.00001206888],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.984775,0.004627056,0.0007772033,0.0005832417,0.0005151505,0.005710628,0.0008709944,0.000139706,0.002001034],"genre_scores_gemma":[0.9791541,0.003260436,0.002619459,0.001314505,0.0008062058,0.009010777,0.001098018,0.00003573031,0.002700716],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006955231,"threshold_uncertainty_score":0.02326757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0411457160423803,"score_gpt":0.3201560973376661,"score_spread":0.2790103812952858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}