{"id":"W4283714328","doi":"10.1097/01.hs9.0000846716.90763.d0","title":"P962: CHANGE IN SOLUBLE BCMA LEVEL MAY BE A SURROGATE MARKER OF EARLY RESPONSE TO THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): PRELIMINARY RESULTS FROM A PHASE I STUDY OF CEVOSTAMAB","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Multiple myeloma; Oncology; Internal medicine; Cytokine release syndrome; Biomarker; Refractory (planetary science); Surrogate endpoint; Gastroenterology; Immunology; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000845972,0.000266238,0.0006439071,0.0002893759,0.00008064776,0.000007120866,0.0002564767,0.00008178947,0.0006735317],"category_scores_gemma":[0.0002194823,0.0002178218,0.00008069232,0.0007598936,0.00007700624,0.0001201612,0.0003151494,0.000515335,0.000006164778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574114,"about_ca_system_score_gemma":0.0002229084,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0153404,"about_ca_topic_score_gemma":0.002385046,"domain_scores_codex":[0.9964825,0.0006762607,0.0007172276,0.0005506768,0.001115818,0.0004575079],"domain_scores_gemma":[0.9981015,0.0007249612,0.0002218751,0.0005805346,0.0001866565,0.0001845203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4363626,0.009476086,0.5233063,0.00004864031,0.00009672887,0.0003430477,0.01976613,0.00001574961,0.002094267,8.274432e-7,0.000423764,0.008065864],"study_design_scores_gemma":[0.05076833,0.04279929,0.8988377,0.000239951,0.00001700203,0.000002772545,0.003740482,0.0001092397,0.000796583,0.000002977819,0.00248407,0.000201621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948288,0.0003208565,5.029758e-7,0.0007434326,0.00007853693,0.002655374,0.001221295,0.00001637762,0.0001347806],"genre_scores_gemma":[0.9966614,0.00002327996,0.0002705215,0.0001714786,0.00003063528,0.0003413735,0.0001963776,0.00005084211,0.002254046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3855942,"threshold_uncertainty_score":0.9912165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0712361846644057,"score_gpt":0.3279748940879443,"score_spread":0.2567387094235386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}