{"id":"W4283714328","doi":"10.1097/01.hs9.0000846716.90763.d0","title":"P962: CHANGE IN SOLUBLE BCMA LEVEL MAY BE A SURROGATE MARKER OF EARLY RESPONSE TO THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): PRELIMINARY RESULTS FROM A PHASE I STUDY OF CEVOSTAMAB","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Multiple myeloma; Oncology; Internal medicine; Cytokine release syndrome; Biomarker; Refractory (planetary science); Surrogate endpoint; Gastroenterology; Immunology; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001246373,0.000570658,0.0008712955,0.00024092,0.0002289867,0.0008049618,0.0004214246,0.000580194,0.001762737],"category_scores_gemma":[0.001321517,0.0002152269,0.0004797777,0.0003039762,0.0003146689,0.000380884,0.0002817237,0.001416248,0.0005135679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005224324,"about_ca_system_score_gemma":0.0003946132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004084097,"about_ca_topic_score_gemma":0.0006308627,"domain_scores_codex":[0.9996071,0.0001485685,0.00002339954,0.0000880836,0.00009556016,0.00003729211],"domain_scores_gemma":[0.999203,0.0001961631,0.0002766647,0.00005182012,0.00007359471,0.000198719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3030496,0.0125146,0.405084,0.0006326751,0.00179475,0.000608784,0.0002958855,0.002967333,0.1292087,0.0001299134,0.003803764,0.13991],"study_design_scores_gemma":[0.02625133,0.177844,0.7501639,0.0000567257,0.001009667,0.002386537,0.0001355325,0.005969448,0.03071061,0.0002495219,0.005156321,0.00006637898],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971492,0.001078933,0.0002480355,0.0001496444,0.00002215061,0.0001668373,0.0005516417,0.0000285719,0.0006051828],"genre_scores_gemma":[0.9974338,0.0002392363,0.0005011462,0.0001335195,0.00003908614,0.0001339362,0.0008694276,0.000007138783,0.0006427261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762737,"threshold_uncertainty_score":0.006591558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0712361846644057,"score_gpt":0.3279748940879443,"score_spread":0.2567387094235386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}