{"id":"W4283715614","doi":"10.1172/jci151666","title":"Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Provincial Health Services Authority; Maze Therapeutics; BeiGene; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; National Human Genome Research Institute; Agios Pharmaceuticals; Foghorn Therapeutics; Parker Institute for Cancer Immunotherapy; Leukemia and Lymphoma Society; G. Harold and Leila Y. Mathers Foundation; BC Children’s Hospital Foundation; BC Children's Hospital; Howard Hughes Medical Institute; Biogen; Dana-Farber/Harvard Cancer Center; Children's Hospital Foundation; Conquer Cancer Foundation; National Heart, Lung, and Blood Institute; Pfizer; Cancer Research Institute","keywords":"Psychological repression; Merkel cell carcinoma; Epigenetics; Human leukocyte antigen; Biology; Carcinoma; Cancer research; Merkel cell; Virology; Immunology; Genetics; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315929,0.0001556015,0.0002181435,0.0002229134,0.0001392392,0.0002804015,0.0001685195,0.0001897382,0.001154629],"category_scores_gemma":[0.000178132,0.00009497908,0.0001467058,0.0001360415,0.0001755958,0.0001231686,0.0001533947,0.0003939806,0.0002348806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002195745,"about_ca_system_score_gemma":0.0001796886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003998699,"about_ca_topic_score_gemma":0.00109953,"domain_scores_codex":[0.9999053,0.00001543319,0.00001063823,0.00001617572,0.00003193677,0.00002044101],"domain_scores_gemma":[0.9999105,0.00002327118,0.00001966602,0.00001692151,0.000007007321,0.0000225818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006338116,0.00003864806,0.0006151939,0.00002885905,0.000003866618,0.0001352977,0.00001060336,0.00007653697,0.9963929,0.00009899623,0.00004467398,0.002490854],"study_design_scores_gemma":[0.00002684385,0.0007322131,0.01333103,0.000004533871,0.00001390667,0.001420132,0.00004708928,0.0009362518,0.9810415,0.00005592209,0.002386152,0.000004335113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968694,0.001070445,0.0007396145,0.00006612887,0.00001131444,0.00002226408,0.0001564814,0.00006492767,0.0009994585],"genre_scores_gemma":[0.9981635,0.0003325232,0.0005291896,0.00002473839,0.000003056679,0.00001110835,0.0001567771,0.000007541983,0.0007715916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154629,"threshold_uncertainty_score":0.003862619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05208735660083123,"score_gpt":0.3560788127783829,"score_spread":0.3039914561775517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}