{"id":"W4283715614","doi":"10.1172/jci151666","title":"Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Provincial Health Services Authority; Maze Therapeutics; BeiGene; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; National Human Genome Research Institute; Agios Pharmaceuticals; Foghorn Therapeutics; Parker Institute for Cancer Immunotherapy; Leukemia and Lymphoma Society; G. Harold and Leila Y. Mathers Foundation; BC Children’s Hospital Foundation; BC Children's Hospital; Howard Hughes Medical Institute; Biogen; Dana-Farber/Harvard Cancer Center; Children's Hospital Foundation; Conquer Cancer Foundation; National Heart, Lung, and Blood Institute; Pfizer; Cancer Research Institute","keywords":"Psychological repression; Merkel cell carcinoma; Epigenetics; Human leukocyte antigen; Biology; Carcinoma; Cancer research; Merkel cell; Virology; Immunology; Genetics; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001113645,0.00006579467,0.000363996,0.0001295591,0.00003777738,0.000003770885,0.00006188529,0.00008928795,0.0000497856],"category_scores_gemma":[0.0006596898,0.00005129438,0.0001368617,0.0001331162,0.0001500794,0.00006901217,0.00005469759,0.0005493728,7.285674e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003018751,"about_ca_system_score_gemma":0.0003070353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003686363,"about_ca_topic_score_gemma":0.000001129222,"domain_scores_codex":[0.9979811,0.0003220602,0.001161679,0.0001156542,0.0003305162,0.00008898769],"domain_scores_gemma":[0.9985713,0.0002499493,0.0007665043,0.0001138275,0.00007515043,0.0002233207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008136138,0.0004270352,0.9679665,0.00008965933,0.00002904184,0.0001283577,0.0002704988,0.0003857379,0.02430691,0.00005563755,0.001931851,0.00359517],"study_design_scores_gemma":[0.003904805,0.001597907,0.9838283,0.0001620459,0.0002087756,0.00006859029,0.0002005554,0.001753592,0.006084516,0.001399404,0.0007232691,0.00006821351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959825,0.002172283,0.000008272125,0.001129529,0.0002832844,0.00009523061,0.000004173375,0.000002688905,0.0003220695],"genre_scores_gemma":[0.9985471,0.0002509592,0.0004812493,0.000413722,0.0001367323,0.000001377385,0.000003945903,0.000007732478,0.000157177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0182224,"threshold_uncertainty_score":0.2386782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05208735660083123,"score_gpt":0.3560788127783829,"score_spread":0.3039914561775517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}