{"id":"W4283717199","doi":"10.3389/fimmu.2022.907591","title":"Immune-Mediated Hepatitis During Immune Checkpoint Inhibitor cancer Immunotherapy: Lessons From Autoimmune Hepatitis and Liver Immunology","year":2022,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Liver Foundation; American Association for the Study of Liver Diseases","keywords":"Immunotherapy; Autoimmune hepatitis; Immune system; Medicine; Immunology; Cancer immunotherapy; Cancer; Hepatitis; Immune checkpoint; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006071589,0.0004906967,0.0008827683,0.001053874,0.0001779186,0.0006960117,0.0004695508,0.00105408,0.001285312],"category_scores_gemma":[0.0007671447,0.0001491321,0.0004127226,0.001111901,0.0004850113,0.001308912,0.0005075113,0.001962384,0.0005850254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004734629,"about_ca_system_score_gemma":0.0008042653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005664132,"about_ca_topic_score_gemma":0.001047002,"domain_scores_codex":[0.9998228,0.00004872244,0.00002532303,0.00002478934,0.00006001496,0.00001834222],"domain_scores_gemma":[0.9996322,0.0002018546,0.00004567283,0.00001129678,0.00008204427,0.00002698634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001000722,0.0000614891,0.0002794378,0.01426901,0.0001024993,0.000316855,0.00007841074,0.0003283302,0.001967968,0.005461384,0.02504481,0.9519897],"study_design_scores_gemma":[0.00003608777,0.0002035793,0.002154471,0.006180082,0.0001489415,0.004514299,0.0001177946,0.0002307378,0.001029134,0.006536697,0.9788221,0.00002603672],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000108801,0.9987028,0.0001076361,0.0004143247,0.0002429808,0.000001533803,0.000003755741,0.000003247773,0.0004150275],"genre_scores_gemma":[0.001081798,0.9976977,0.0001322568,0.0003355298,0.0004268621,0.000003128424,0.00001105059,0.000001045923,0.0003107171],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001285312,"threshold_uncertainty_score":0.004299819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923303325363372,"score_gpt":0.2800520740005892,"score_spread":0.2608190407469555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}