{"id":"W4283721607","doi":"10.1101/2022.06.27.497754","title":"Centrin-deficient <i>Leishmania mexicana</i> confers protection against Old World visceral leishmaniasis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Global Health Innovative Technology Fund","keywords":"Leishmania donovani; Visceral leishmaniasis; Leishmaniasis; Leishmania mexicana; Immunology; Biology; Disease; Parasitic disease; Immunization; Spleen; Interleukin 10; Leishmania; Virology; Immune system; Medicine; Parasite hosting; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155949,0.0003380152,0.0002315789,0.000226161,0.0001631136,0.0003810074,0.0002355871,0.0004050118,0.002343288],"category_scores_gemma":[0.00009047223,0.0001277927,0.0002114014,0.00009554921,0.000256944,0.0001908771,0.0001729473,0.0007994572,0.0004368275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003079462,"about_ca_system_score_gemma":0.0001317527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027144,"about_ca_topic_score_gemma":0.001123415,"domain_scores_codex":[0.9998826,0.00001654044,0.00001152996,0.00003210402,0.00002461245,0.00003265038],"domain_scores_gemma":[0.999884,0.0000113203,0.00004019405,0.00001279063,0.00001309363,0.00003856785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001865785,0.00005643269,0.0002005873,0.0000536333,0.000009691792,0.00004385306,0.00001119476,0.00004826184,0.9984069,0.00007492868,0.0001492484,0.0007586896],"study_design_scores_gemma":[0.00009336149,0.001463782,0.01326593,0.00003004206,0.00007485527,0.00077698,0.0001347252,0.001293787,0.968487,0.00007901815,0.01428157,0.00001898484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941999,0.0007563418,0.001566424,0.0002868845,0.00007035062,0.00004643603,0.001146499,0.0001465095,0.001780783],"genre_scores_gemma":[0.9921414,0.0004336903,0.0009495823,0.0001495388,0.00001295601,0.00004304356,0.001291977,0.00003810082,0.004939736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343288,"threshold_uncertainty_score":0.007839084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02690670273339489,"score_gpt":0.2566726246808435,"score_spread":0.2297659219474485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}