{"id":"W4283724849","doi":"10.1242/dev.200391","title":"Absence of a robust mitotic timer mechanism in early preimplantation mouse embryos leads to chromosome instability","year":2022,"lang":"en","type":"article","venue":"Development","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Université de Montréal; Fondation Jean-Louis Lévesque; McGill University","keywords":"Biology; Mitosis; Embryo; Cell biology; Mechanism (biology); Chromosome instability; Timer; Genetics; Instability; Genome instability; Chromosome; DNA; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009588918,0.0001629965,0.0002519716,0.0004798558,0.0003164134,0.0003626806,0.0002531547,0.0007866679,0.004468552],"category_scores_gemma":[0.0009480078,0.0001640107,0.0001948182,0.0001861723,0.0003501582,0.0003161133,0.0005112335,0.0007141546,0.0006056643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969554,"about_ca_system_score_gemma":0.0002404051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002324371,"about_ca_topic_score_gemma":0.000295844,"domain_scores_codex":[0.9996023,0.00009195128,0.00005131515,0.00007031966,0.0001254615,0.00005867851],"domain_scores_gemma":[0.9993967,0.0001627196,0.0001719783,0.00008900217,0.00006615739,0.0001133919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005940924,0.00006478873,0.007608895,0.0001290155,0.00001772848,0.001078459,0.000249424,0.00006182567,0.9636331,0.001827651,0.001431718,0.0233033],"study_design_scores_gemma":[0.00008497829,0.001497133,0.0895277,0.0001119341,0.00008693933,0.005634717,0.0005886805,0.0006187437,0.8163832,0.001695297,0.08371165,0.0000589749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96203,0.007872891,0.009871814,0.003465415,0.001082748,0.0001070876,0.0006921692,0.0003850008,0.01449297],"genre_scores_gemma":[0.9585338,0.003826385,0.003647257,0.001379348,0.0001840406,0.0001368839,0.000500428,0.0001030113,0.03168888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004468552,"threshold_uncertainty_score":0.01494884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971658864212368,"score_gpt":0.2599294576965731,"score_spread":0.2302128690544494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}