{"id":"W4283724849","doi":"10.1242/dev.200391","title":"Absence of a robust mitotic timer mechanism in early preimplantation mouse embryos leads to chromosome instability","year":2022,"lang":"en","type":"article","venue":"Development","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Université de Montréal; Fondation Jean-Louis Lévesque; McGill University","keywords":"Biology; Mitosis; Embryo; Cell biology; Mechanism (biology); Chromosome instability; Timer; Genetics; Instability; Genome instability; Chromosome; DNA; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000548489,0.00009188448,0.0002120724,0.0001061628,0.00006492634,0.000001967781,0.00008452864,0.00003903579,0.0001822909],"category_scores_gemma":[0.000104645,0.00008628836,0.00002388648,0.0002343097,0.00003379725,0.00003820039,0.0001080519,0.0001593734,0.00002629075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535115,"about_ca_system_score_gemma":0.000220347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005023935,"about_ca_topic_score_gemma":0.00002445507,"domain_scores_codex":[0.9988709,0.00009213077,0.0003166771,0.0003485098,0.0002071168,0.0001646538],"domain_scores_gemma":[0.9995456,0.00002515104,0.00005759549,0.000249226,0.00006554372,0.00005683311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003794326,0.001158982,0.4916145,0.0002203672,0.00007996929,0.00004791416,0.01610767,0.0003962203,0.4826966,0.0002404513,0.00012209,0.003521006],"study_design_scores_gemma":[0.0003905381,0.0001990636,0.8824996,0.00001304402,0.000005278654,0.00001445302,0.00014644,0.00001849448,0.116358,0.0000762319,0.0001991805,0.00007968633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984607,0.00002723107,0.0003218367,0.0001887909,0.0001286974,0.0006571957,0.000008510428,0.00002158863,0.0001854292],"genre_scores_gemma":[0.9959638,0.000001384088,0.003201474,0.0001265014,0.00001267689,0.0001597301,0.0000302953,0.000006717159,0.0004973953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3908851,"threshold_uncertainty_score":0.3518737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971658864212368,"score_gpt":0.2599294576965731,"score_spread":0.2302128690544494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}