{"id":"W4283727826","doi":"10.1093/nar/gkac541","title":"Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"College of Natural Resources and Sciences, Humboldt State University; Institut National Du Cancer; Ligue Contre le Cancer; Université de Strasbourg; Laboratoire d'Excellence INRT; Institut National de la Santé et de la Recherche Médicale; King Abdulaziz University; Agence Nationale de la Recherche; Centre National de la Recherche Scientifique; CNIB","keywords":"Biology; Histone H3; Transcription (linguistics); Genetics; Spermatogenesis; X-inactivation; Histone; Piwi-interacting RNA; X chromosome; Cell biology; Epigenetics; Transcription factor; Gene; Genome; Transposable element; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130648,0.0003226837,0.0002540687,0.0001855931,0.0002172573,0.0004501467,0.0002569525,0.0003362505,0.002644399],"category_scores_gemma":[0.0001066357,0.0001918176,0.0003824859,0.0001204978,0.0004027282,0.0002501524,0.0004463505,0.0004854722,0.0007788468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001690037,"about_ca_system_score_gemma":0.0001647535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003142387,"about_ca_topic_score_gemma":0.0005177487,"domain_scores_codex":[0.999806,0.000016905,0.00001143536,0.00008098281,0.00005055595,0.00003417953],"domain_scores_gemma":[0.9998707,0.000009990388,0.00003299869,0.0000156467,0.00001363824,0.00005707319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005722421,0.000007615507,0.0006085792,0.00003773527,0.000004045356,0.00004823644,0.000009919298,0.000007837522,0.9983118,0.00007981566,0.00002091821,0.0008062576],"study_design_scores_gemma":[0.00003472697,0.0003053295,0.05122391,0.00001963822,0.00002983144,0.001068407,0.00007669816,0.0006808112,0.9415558,0.000224407,0.004765673,0.00001467022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758881,0.009671126,0.00927002,0.000320151,0.0001045275,0.00003095519,0.001185269,0.0003050928,0.003224807],"genre_scores_gemma":[0.9905042,0.001165616,0.002690259,0.0001511214,0.0000181124,0.00002350821,0.0008656257,0.00006055742,0.004521027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002644399,"threshold_uncertainty_score":0.008846343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003661741482996,"score_gpt":0.3219196911933042,"score_spread":0.3018830737784742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}