{"id":"W4283733035","doi":"10.1093/humrep/deac104.039","title":"P-564 Advanced paternal age is associated with higher rate of segmental chromosomal aberrations in preimplantation embryos","year":2022,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; CReATe Fertility Centre","funders":"","keywords":"Aneuploidy; Biology; Andrology; Embryo transfer; In vitro fertilisation; Embryo; Advanced maternal age; Gynecology; Live birth; Sperm; Fertility; Pregnancy; Genetics; Medicine; Chromosome; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042939,0.00008287707,0.0001525164,0.00009199083,0.0001358874,0.000007669014,0.0000376274,0.00002671239,0.0003091085],"category_scores_gemma":[0.00005766446,0.00008006537,0.00002744832,0.0002054887,0.00003485673,0.00008484576,0.00003135268,0.0001744388,0.000002428438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000139947,"about_ca_system_score_gemma":0.00002915518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002273356,"about_ca_topic_score_gemma":0.00009236526,"domain_scores_codex":[0.9990836,0.0000786266,0.0002206968,0.0002917975,0.00020532,0.0001199242],"domain_scores_gemma":[0.9995297,0.00002101102,0.0001588013,0.0002115626,0.00004785321,0.00003106128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002693719,0.002823035,0.2712554,0.000192506,0.0003464869,0.0006139156,0.006668197,0.009984571,0.6914818,0.0006974069,0.005570634,0.007672389],"study_design_scores_gemma":[0.0028126,0.001247651,0.9536905,0.000124035,0.00007922278,0.00009346932,0.000268749,0.0001053136,0.04100468,0.0001828775,0.0002599021,0.0001310546],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981472,0.00004800118,0.00002074481,0.000183462,0.0001632169,0.0003196409,0.00003903624,0.00005316092,0.001025508],"genre_scores_gemma":[0.9958666,0.000004131483,0.0001284767,0.00006863765,0.00009534395,0.00006390273,0.0005861068,0.00001416137,0.003172643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6824351,"threshold_uncertainty_score":0.3384522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700729634181345,"score_gpt":0.2787690960943463,"score_spread":0.2517617997525329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}