{"id":"W4283734180","doi":"10.3390/pharmaceutics14071376","title":"Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Transporter; Blood–brain barrier; Placenta; Drug; Pharmacology; Solute carrier family; Medicine; Neuroscience; Biology; Central nervous system; Pregnancy; Fetus; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004150215,0.0006709101,0.001214936,0.001554616,0.0002441595,0.001178651,0.0005480687,0.0009817034,0.003229746],"category_scores_gemma":[0.0006722336,0.0002226232,0.0006541131,0.001473486,0.0004108439,0.001424164,0.0005974282,0.001233097,0.001101694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005919337,"about_ca_system_score_gemma":0.001065175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183775,"about_ca_topic_score_gemma":0.001468371,"domain_scores_codex":[0.9998316,0.00003755788,0.00003147802,0.00003475577,0.00004367165,0.0000210138],"domain_scores_gemma":[0.9997213,0.0001453048,0.00004174626,0.000006586101,0.00007001404,0.00001513151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001847089,0.00009383081,0.0005084757,0.04876195,0.0001941574,0.0007963925,0.0002195432,0.0006994072,0.007446863,0.009284144,0.02747018,0.9043403],"study_design_scores_gemma":[0.00001527295,0.0001740702,0.001540165,0.006647584,0.0002905807,0.003424702,0.0001558737,0.0002354428,0.00232823,0.003041994,0.9821144,0.0000317191],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002152543,0.9985839,0.0001613537,0.0003002125,0.0001086898,0.000003176862,0.00002034147,0.000007057884,0.0006000105],"genre_scores_gemma":[0.00121158,0.9979949,0.0001461303,0.0001526256,0.00009516341,0.000004216498,0.00002577647,0.000001553827,0.0003681419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003229746,"threshold_uncertainty_score":0.01080453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1197591543258185,"score_gpt":0.4275708432918215,"score_spread":0.307811688966003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}