{"id":"W4283734180","doi":"10.3390/pharmaceutics14071376","title":"Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Transporter; Blood–brain barrier; Placenta; Drug; Pharmacology; Solute carrier family; Medicine; Neuroscience; Biology; Central nervous system; Pregnancy; Fetus; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004227807,0.0003642434,0.001051639,0.0002765639,0.00009204668,0.00001407599,0.00009124514,0.0002225522,0.00102433],"category_scores_gemma":[0.00008821982,0.0003068486,0.0002247668,0.0003024144,0.0000918959,0.00004907442,0.00001514976,0.001117685,0.000008144851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002592122,"about_ca_system_score_gemma":0.0002527041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004655836,"about_ca_topic_score_gemma":0.00001215106,"domain_scores_codex":[0.9981298,0.000154393,0.0004939307,0.0004928446,0.0003939412,0.0003350931],"domain_scores_gemma":[0.999088,0.0003183925,0.00008720308,0.0002230248,0.00001952048,0.0002637905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000497354,0.0002369053,0.00002520824,0.02435256,0.0001726735,0.0007032904,0.0006221826,0.000001448862,0.00002232071,0.002118342,0.0001757478,0.971072],"study_design_scores_gemma":[0.001223957,0.000158954,0.00002330968,0.00497736,0.001080553,0.00007239944,0.00008624237,0.00004507758,0.00008112357,0.0005292993,0.9914174,0.0003043189],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002245211,0.9936678,0.0002578266,0.001662205,0.0003364796,0.00246511,0.0001238814,0.00006306925,0.001401181],"genre_scores_gemma":[0.001220419,0.9971325,0.0001181556,0.0004763483,0.0001414703,0.0003286849,0.0001517971,0.00008361706,0.0003470311],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9912416,"threshold_uncertainty_score":0.9999384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1197591543258185,"score_gpt":0.4275708432918215,"score_spread":0.307811688966003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}