{"id":"W4283734564","doi":"10.1097/01.hs9.0000849024.60193.ea","title":"P1542: COMORBIDITIES AND COMPLICATIONS ACROSS GENOTYPES IN ADULT PATIENTS WITH PYRUVATE KINASE DEFICIENCY: ANALYSIS FROM THE PEAK REGISTRY","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Missense mutation; Medicine; Pyruvate kinase deficiency; Genotype; Internal medicine; Pediatrics; Compound heterozygosity; Frameshift mutation; Gastroenterology; Pyruvate kinase; Allele; Genetics; Mutation; Gene; Biology; Glycolysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00108889,0.0002923727,0.0005839824,0.00144119,0.0004342599,0.000879765,0.0005888408,0.0003782596,0.001899589],"category_scores_gemma":[0.003067313,0.000273106,0.0006336859,0.003452647,0.0002036995,0.0007223799,0.001169287,0.0006443694,0.0005198927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003534704,"about_ca_system_score_gemma":0.0007364044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004473956,"about_ca_topic_score_gemma":0.004942427,"domain_scores_codex":[0.9988652,0.0001755989,0.0002063527,0.0003701715,0.0002368582,0.0001457907],"domain_scores_gemma":[0.9974585,0.0003471464,0.001318615,0.0002618729,0.0003055959,0.0003082704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001301504,0.00001513331,0.9979133,0.00002116055,0.00004987627,0.00009420915,0.00003554184,0.00003824726,0.00006614586,0.00002481558,0.0006567955,0.0009546558],"study_design_scores_gemma":[0.0000207775,0.00006573538,0.998126,0.00002116954,0.00005016795,0.0005666552,0.0002479654,0.0002261908,0.00004976183,0.00003274384,0.0005869378,0.000005973975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853538,0.0002883449,0.0001835351,0.00007047715,0.000009099166,0.00005519948,0.01312645,0.00001422304,0.00089878],"genre_scores_gemma":[0.9814755,0.0003397237,0.0002632972,0.0001006196,0.00003226146,0.0001538408,0.01743555,0.00001445255,0.000184708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004473956,"threshold_uncertainty_score":0.008895814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339552114506611,"score_gpt":0.2466472623407824,"score_spread":0.2332517411957162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}