{"id":"W4283739205","doi":"10.1101/2022.06.26.495014","title":"Genotyping, sequencing and analysis of 140,000 adults from the Mexico City Prospective Study","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Medical Research Council; University of Oxford; Cancer Research UK; British Heart Foundation; Wellcome Trust; National Institute for Health and Care Research; Regeneron Pharmaceuticals; Universidad Nacional Autónoma de México; AstraZeneca","keywords":"1000 Genomes Project; Genotyping; Exome sequencing; Imputation (statistics); Allele frequency; Biology; Population; Ancestry-informative marker; Genetics; Indigenous; Exome; Genotype; Geography; Evolutionary biology; Demography; Single-nucleotide polymorphism; Missing data; Gene; Mutation; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007459486,0.0002872936,0.0002168682,0.0008683566,0.000838961,0.0006069405,0.0003644869,0.0004317568,0.002589566],"category_scores_gemma":[0.001407678,0.0003200977,0.0002223971,0.001376095,0.0001452218,0.0001179708,0.0004486418,0.0003725446,0.0004976284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003524966,"about_ca_system_score_gemma":0.000413169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03428031,"about_ca_topic_score_gemma":0.03696069,"domain_scores_codex":[0.9996827,0.00007235825,0.00002207189,0.0001281703,0.00006040479,0.00003435999],"domain_scores_gemma":[0.9996328,0.00005919917,0.00009138497,0.00008519624,0.00007870533,0.00005273152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005908861,0.00006101503,0.9717065,0.00005162126,0.0002444501,0.0003241323,0.0005317029,0.0004245656,0.003574757,0.0002269257,0.009215324,0.01304807],"study_design_scores_gemma":[0.00005722399,0.0000455038,0.9934226,0.00001788349,0.00007363138,0.0001543282,0.0001427222,0.0003124108,0.0003088503,0.00006524312,0.005392127,0.000007479586],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592426,0.0003948968,0.001909361,0.0002515868,0.00001770098,0.000134271,0.03619806,0.0000500339,0.001801522],"genre_scores_gemma":[0.9335465,0.0006955722,0.005917164,0.0003891127,0.00005561519,0.0007217881,0.05476059,0.00006574504,0.003847865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03428031,"threshold_uncertainty_score":0.06816155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01416729877662546,"score_gpt":0.2406753165954736,"score_spread":0.2265080178188481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}