{"id":"W4283740876","doi":"10.3390/pharmaceutics14071391","title":"PEG-Free Polyion Complex Nanocarriers for Brain-Derived Neurotrophic Factor","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Toronto; International Rett Syndrome Foundation","keywords":"Ethylene glycol; PEG ratio; Sarcosine; Nanocarriers; Chemistry; Nanoparticle; Copolymer; Polymer; Biophysics; Combinatorial chemistry; Nanotechnology; Materials science; Organic chemistry; Biochemistry; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256267,0.0003170393,0.0001534605,0.0001079114,0.00009992202,0.0002346581,0.0001872471,0.0003757542,0.000909724],"category_scores_gemma":[0.0001861052,0.000104011,0.0001851865,0.00007659633,0.0001734841,0.0003486372,0.000166526,0.0004106835,0.0005255215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003030321,"about_ca_system_score_gemma":0.0001568009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000339231,"about_ca_topic_score_gemma":0.0004817092,"domain_scores_codex":[0.9998845,0.0000141554,0.00001020776,0.00002955263,0.0000438884,0.00001765848],"domain_scores_gemma":[0.999928,0.00001706868,0.0000273443,0.000008972801,0.000009261505,0.000009323628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004904047,0.00001638272,0.00004696642,0.00004438658,0.000005896437,0.00004159161,0.00001684824,0.0002482501,0.9968885,0.0001997965,0.00004815119,0.002394193],"study_design_scores_gemma":[0.0000107193,0.0001608562,0.0003003808,0.000003613401,0.000008202776,0.00007899717,0.000003556583,0.001224473,0.9955656,0.00002932363,0.00260943,0.000004912843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508284,0.003491564,0.04081311,0.0002253347,0.00008758705,0.0002389074,0.0001833866,0.0003150226,0.003816654],"genre_scores_gemma":[0.9720693,0.0009658989,0.02120296,0.0001569093,0.00001723528,0.0001166171,0.0002181498,0.00004627928,0.005206707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000909724,"threshold_uncertainty_score":0.003043294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1870700535257645,"score_gpt":0.3744243379363654,"score_spread":0.1873542844106009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}