{"id":"W4283740876","doi":"10.3390/pharmaceutics14071391","title":"PEG-Free Polyion Complex Nanocarriers for Brain-Derived Neurotrophic Factor","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Toronto; International Rett Syndrome Foundation","keywords":"Ethylene glycol; PEG ratio; Sarcosine; Nanocarriers; Chemistry; Nanoparticle; Copolymer; Polymer; Biophysics; Combinatorial chemistry; Nanotechnology; Materials science; Organic chemistry; Biochemistry; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381003,0.0001631154,0.0001389241,0.00008814709,0.0009905231,0.00005357835,0.0005101336,0.0000295438,0.0004483869],"category_scores_gemma":[0.0002836174,0.000166963,0.0001155179,0.0002503151,0.00009746785,0.0001246929,0.0002570177,0.0002663633,0.00001180418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007707107,"about_ca_system_score_gemma":0.00006353788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002768858,"about_ca_topic_score_gemma":0.000001064994,"domain_scores_codex":[0.9983791,0.0002961472,0.0002227879,0.0003884584,0.0003610824,0.0003524375],"domain_scores_gemma":[0.999154,0.0002512163,0.0001153677,0.0003176707,0.00003155283,0.0001302231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001492399,0.00006671425,0.00004026893,0.00002071438,0.000005116285,0.00001076592,0.0001963405,0.000731237,0.9890937,0.0019823,0.006292726,0.001410945],"study_design_scores_gemma":[0.00111685,0.0001814624,0.00008646839,0.000001160309,0.00001703352,0.00003014211,0.0000286765,0.0184117,0.7951531,0.000521717,0.1842657,0.0001859859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823954,0.00007592405,0.001602468,0.01103172,0.00238957,0.0009525941,0.0008990861,0.0002042309,0.0004490743],"genre_scores_gemma":[0.9826989,0.00002082344,0.0002426628,0.0158017,0.0002450741,0.0001357284,0.00003206592,0.00003924999,0.0007838118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1939405,"threshold_uncertainty_score":0.7618403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1870700535257645,"score_gpt":0.3744243379363654,"score_spread":0.1873542844106009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}