{"id":"W4283745047","doi":"10.1038/s41467-022-31430-0","title":"The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Multiple Myeloma Research Foundation; National Cancer Institute; Prostate Cancer Foundation; Howard Hughes Medical Institute","keywords":"Multiple myeloma; Lenalidomide; Drug resistance; Disease; Biology; Medicine; Malignancy; Oncology; Bioinformatics; Cancer research; Immunology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003233093,0.00009134016,0.0001475469,0.00006164317,0.001015367,0.00001218974,0.0005321884,0.00005944817,0.00001373295],"category_scores_gemma":[0.0003809401,0.00006848784,0.00006421345,0.0002183201,0.0001937414,0.00002679869,0.0005888662,0.0008367207,0.000002425648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000983661,"about_ca_system_score_gemma":0.00009347653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003259645,"about_ca_topic_score_gemma":0.001658402,"domain_scores_codex":[0.9987578,0.0003557538,0.0002050671,0.000161682,0.0003497326,0.000169958],"domain_scores_gemma":[0.9971047,0.0007763407,0.0001072898,0.001793608,0.0001226175,0.00009541839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008258075,0.007621597,0.492956,0.0005080798,0.003333661,0.0002103041,0.004347209,0.00003542034,0.2182926,0.1050818,0.05957707,0.09977829],"study_design_scores_gemma":[0.004570311,0.0002827336,0.6872023,0.00005297801,0.0001398878,0.00006148063,0.0007174707,0.001120852,0.008910454,0.002504809,0.2942218,0.0002149308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8930902,0.08524843,0.0001158772,0.01678083,0.0001649117,0.00150717,0.0002102655,0.00008860481,0.00279366],"genre_scores_gemma":[0.9869056,0.001687972,0.01000607,0.0001499717,0.000008392485,0.0001964229,0.00007974818,0.00001592338,0.0009498337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2346448,"threshold_uncertainty_score":0.7809484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02387925602898617,"score_gpt":0.3149509845224097,"score_spread":0.2910717284934236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}