{"id":"W4283745319","doi":"10.1093/jas/skac235","title":"Sustained vascular contractile response induced by an R- and S-epimer of the ergot alkaloid ergocristine and attenuation by a noncompetitive antagonist","year":2022,"lang":"en","type":"article","venue":"Journal of Animal Science","topic":"Plant and fungal interactions","field":"Agricultural and Biological Sciences","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Agriculture - Saskatchewan","keywords":"Phenoxybenzamine; Epimer; Antagonist; Vasoconstriction; Chemistry; Contraction (grammar); Stereochemistry; Alkaloid; Pharmacology; Internal medicine; Endocrinology; Biology; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00115469,0.00007462584,0.0001369472,0.00001964097,0.0006678028,0.00007230034,0.0002641525,0.00001969734,0.00004856816],"category_scores_gemma":[0.0001861927,0.00002959686,0.00004428824,0.000390788,0.0002349316,0.0004392548,0.0001427472,0.0002149825,1.805593e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004344807,"about_ca_system_score_gemma":0.00004954799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001964148,"about_ca_topic_score_gemma":0.00004355454,"domain_scores_codex":[0.998868,0.0001873179,0.0002303445,0.0001471986,0.000414516,0.0001525588],"domain_scores_gemma":[0.9991037,0.0002642474,0.0003169427,0.00003293228,0.0001788092,0.0001033797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006114964,0.0001293568,0.001518512,9.48192e-7,0.000005794269,0.000002563536,0.00013229,6.149641e-7,0.9963627,0.00003998299,0.0006182302,0.0005775013],"study_design_scores_gemma":[0.001103584,0.007359575,0.5274073,0.0000369983,0.00007305393,0.0004574393,0.009219685,0.0003821156,0.4223249,0.0001335204,0.03118663,0.0003152473],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972614,0.0001736492,0.000001771583,0.002151346,0.00008708252,0.00008071316,0.0001408477,0.000003421623,0.00009978421],"genre_scores_gemma":[0.9996469,0.00002932528,0.00002137092,0.0002216385,0.00003523742,0.000001756241,0.000003752352,5.802929e-7,0.00003944386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5740378,"threshold_uncertainty_score":0.5136266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126433592858385,"score_gpt":0.236147515656486,"score_spread":0.2248831797279022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}