{"id":"W4283745817","doi":"10.1093/humrep/deac107.070","title":"P-074 Sperm deoxyribonucleic acid integrity decreases with age and exhibits a rapid decline beyond the age of 35: a retrospective evaluation of 3446 semen samples","year":2022,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"","keywords":"Semen; Sperm; Infertility; Assisted reproductive technology; Fertility; Medicine; Semen analysis; Gynecology; Abstinence; Live birth; Retrospective cohort study; Demography; Obstetrics; Biology; Andrology; Pregnancy; Population; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001043082,0.0002131365,0.0004804911,0.001416502,0.0004305694,0.0005372574,0.0002992281,0.0002003391,0.001089641],"category_scores_gemma":[0.002360321,0.0002432748,0.0004032524,0.001665326,0.0003654759,0.0003817797,0.0004255966,0.0001821457,0.0005003363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758747,"about_ca_system_score_gemma":0.0003717625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001954084,"about_ca_topic_score_gemma":0.002023769,"domain_scores_codex":[0.9990422,0.000174085,0.000219276,0.0002273739,0.0002655528,0.00007148088],"domain_scores_gemma":[0.9980735,0.0004104873,0.0007128117,0.0002145487,0.0004482483,0.0001405095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001499423,0.00001500376,0.9954695,0.00006677671,0.00004419087,0.0002830886,0.00009877299,0.00002189823,0.0005214314,0.00001396909,0.0001420638,0.00317352],"study_design_scores_gemma":[0.00001162708,0.0003144362,0.9935613,0.00003572776,0.00009692687,0.003354859,0.0002303679,0.0001125927,0.0005960843,0.00001883635,0.001660556,0.000006737568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934336,0.003367587,0.0004569506,0.00002848638,0.000009894372,0.00007512758,0.001974414,0.00001178755,0.0006420088],"genre_scores_gemma":[0.9971028,0.000727494,0.0002518197,0.00003863074,0.00001223443,0.00004016092,0.001640918,0.000004405809,0.0001814752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001954084,"threshold_uncertainty_score":0.00551641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05816059757267138,"score_gpt":0.29955204580778,"score_spread":0.2413914482351086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}