{"id":"W4283753847","doi":"10.3389/fphys.2022.942790","title":"The Diverse Roles of 17β-Estradiol in Non-Gonadal Tissues and Its Consequential Impact on Reproduction in Laying and Broiler Breeder Hens","year":2022,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Animal Nutrition and Physiology","field":"Agricultural and Biological Sciences","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs; Ontario Agri-Food Innovation Alliance; Canada First Research Excellence Fund; University of Guelph","keywords":"Yolk; Biology; Endocrinology; Internal medicine; Estrogen; Follicular phase; Reproduction; Sexual maturity; Estrogen receptor; Hormone; Physiology; Cell biology; Medicine; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722972,0.0002327461,0.0002073205,0.0005134923,0.0001118294,0.0004239025,0.0001527379,0.0002487191,0.0006884299],"category_scores_gemma":[0.0001484825,0.0001173129,0.0001931506,0.0003248713,0.0002117991,0.0002391315,0.0002052659,0.0002084146,0.000147669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113753,"about_ca_system_score_gemma":0.00019094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127477,"about_ca_topic_score_gemma":0.001908527,"domain_scores_codex":[0.999927,0.00001107977,0.00001183514,0.00002267644,0.0000160007,0.00001139052],"domain_scores_gemma":[0.9999392,0.00001868548,0.0000225102,0.000001541029,0.0000129292,0.000005199559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001022839,0.00006540889,0.01751833,0.01119451,0.0002658647,0.003480753,0.0005226217,0.001177727,0.3505132,0.003172809,0.003535376,0.6075305],"study_design_scores_gemma":[0.00005478265,0.00248414,0.3053462,0.002478576,0.001112631,0.0197382,0.001752066,0.0006552215,0.1307468,0.003651104,0.5318236,0.0001565953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09902219,0.8931507,0.001407288,0.0004116067,0.0002267484,0.00001678305,0.00040075,0.00003255276,0.005331285],"genre_scores_gemma":[0.1785716,0.8096196,0.002170105,0.0005492189,0.0002291413,0.00002526304,0.0004464285,0.00001534955,0.008373203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001127477,"threshold_uncertainty_score":0.002303064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03920615577699787,"score_gpt":0.2888150384976319,"score_spread":0.249608882720634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}