{"id":"W4283753847","doi":"10.3389/fphys.2022.942790","title":"The Diverse Roles of 17β-Estradiol in Non-Gonadal Tissues and Its Consequential Impact on Reproduction in Laying and Broiler Breeder Hens","year":2022,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Animal Nutrition and Physiology","field":"Agricultural and Biological Sciences","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs; Ontario Agri-Food Innovation Alliance; Canada First Research Excellence Fund; University of Guelph","keywords":"Yolk; Biology; Endocrinology; Internal medicine; Estrogen; Follicular phase; Reproduction; Sexual maturity; Estrogen receptor; Hormone; Physiology; Cell biology; Medicine; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293346,0.0002224176,0.0008618828,0.00006622656,0.0001073556,0.00001014148,0.0001725299,0.0001970966,0.00005973942],"category_scores_gemma":[0.00004568636,0.00008914091,0.0001083214,0.0002599686,0.000229173,0.00004839508,0.0001130943,0.0003999017,0.000001084298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006443037,"about_ca_system_score_gemma":0.00001974289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004568318,"about_ca_topic_score_gemma":0.0002373606,"domain_scores_codex":[0.9983333,0.0004776287,0.0003682875,0.0004828727,0.00007469967,0.0002632047],"domain_scores_gemma":[0.9994223,0.0002704051,0.000190534,0.00006833424,0.00001178284,0.00003667334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006922871,0.0002454664,0.003516812,0.0007740742,0.00008882171,0.00002655721,0.0002507646,0.00002458818,0.006948848,0.0001799221,0.002603648,0.9846482],"study_design_scores_gemma":[0.001109206,0.00244282,0.3350373,0.001753769,0.00009538169,0.00009018343,0.003387495,0.0001191308,0.00001656034,0.00331774,0.651706,0.00092444],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4699317,0.5292603,4.999801e-8,0.0000700493,0.0002641541,0.000352219,0.00008238897,0.00000540803,0.00003374044],"genre_scores_gemma":[0.2117626,0.7878952,0.000007742666,0.00002557939,0.0001240453,0.00004408692,0.0001163103,0.000001987936,0.00002241896],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837238,"threshold_uncertainty_score":0.3635061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03920615577699787,"score_gpt":0.2888150384976319,"score_spread":0.249608882720634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}