{"id":"W4283760817","doi":"10.1111/mec.16591","title":"Identification of a rapidly‐spreading triple mutant for high‐level metabolic insecticide resistance in <i>Anopheles gambiae</i> provides a real‐time molecular diagnostic for antimalarial intervention deployment","year":2022,"lang":"en","type":"article","venue":"Molecular Ecology","topic":"Malaria Research and Control","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Economic and Social Research Council; Medical Research Council; Royal Society; Medical Research Council Canada; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Piperonyl butoxide; Pyrethroid; Anopheles gambiae; Genetics; Selective sweep; Haplotype; Mutant; Gene duplication; Mutation; Point mutation; Malaria; Gene; Allele; Ecology; Pesticide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001534512,0.0001965031,0.0006693227,0.0004132616,0.0001275218,0.00002408098,0.0002295945,0.0001053416,0.00008393145],"category_scores_gemma":[0.003088301,0.000217144,0.0002970581,0.0003712292,0.00007070061,0.00006877905,0.0001203791,0.0001948224,0.000002033056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296585,"about_ca_system_score_gemma":0.0002766867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002285151,"about_ca_topic_score_gemma":0.0003829362,"domain_scores_codex":[0.9972402,0.0004834791,0.0008723973,0.000533301,0.0003459562,0.0005245924],"domain_scores_gemma":[0.9983504,0.0005566137,0.000372994,0.0003842585,0.0002365297,0.00009924604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004703037,0.0009190195,0.00111761,0.0004638554,0.0003025404,0.0001610862,0.0001230777,0.0001890579,0.9667191,0.02418622,0.0001674442,0.000947971],"study_design_scores_gemma":[0.03179174,0.004533679,0.05126498,0.0001817607,0.0009909449,0.00005393243,0.0002064739,0.008715148,0.8848503,0.01567338,0.001228033,0.0005095821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944892,0.0008339169,0.0459444,0.0018329,0.0002358899,0.005878986,0.0003077284,0.00004134514,0.00003286976],"genre_scores_gemma":[0.9895552,0.00004114654,0.002950711,0.0002037824,0.00004100952,0.006618099,0.0002949194,0.000054743,0.0002403386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08186874,"threshold_uncertainty_score":0.8854874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235378234239365,"score_gpt":0.2788900008613087,"score_spread":0.2665362185189151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}