{"id":"W4283760817","doi":"10.1111/mec.16591","title":"Identification of a rapidly‐spreading triple mutant for high‐level metabolic insecticide resistance in <i>Anopheles gambiae</i> provides a real‐time molecular diagnostic for antimalarial intervention deployment","year":2022,"lang":"en","type":"article","venue":"Molecular Ecology","topic":"Malaria Research and Control","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Economic and Social Research Council; Medical Research Council; Royal Society; Medical Research Council Canada; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Biology; Piperonyl butoxide; Pyrethroid; Anopheles gambiae; Genetics; Selective sweep; Haplotype; Mutant; Gene duplication; Mutation; Point mutation; Malaria; Gene; Allele; Ecology; Pesticide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006280356,0.0002583954,0.000145653,0.0002631967,0.0001598153,0.000187509,0.0001328511,0.0002462603,0.001078129],"category_scores_gemma":[0.000101031,0.0001131148,0.0001894623,0.0001309368,0.0001284723,0.00005052783,0.0001506067,0.0002981656,0.00025351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443806,"about_ca_system_score_gemma":0.00008205701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002256693,"about_ca_topic_score_gemma":0.004969834,"domain_scores_codex":[0.9999585,0.000006113995,0.000003313278,0.00001281212,0.000009128534,0.00001002312],"domain_scores_gemma":[0.9999262,0.00001046195,0.00002595034,0.000006950658,0.000007648787,0.00002276526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008905165,0.00002832285,0.004714939,0.00002008394,0.00001850133,0.0002707374,0.00004925104,0.0000360093,0.9916221,0.00006408708,0.000118731,0.002968239],"study_design_scores_gemma":[0.00005875259,0.001104132,0.5925544,0.00005622366,0.0001353107,0.007636018,0.0005917482,0.002959925,0.387983,0.000202378,0.006662731,0.00005538208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997239,0.0001135316,0.001059101,0.00004311824,0.000008942912,0.00003653867,0.0008047606,0.00005401178,0.0006411333],"genre_scores_gemma":[0.9962174,0.0001039699,0.002090491,0.00005133489,0.000003246275,0.00002435879,0.0007720024,0.00002241018,0.0007146582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002256693,"threshold_uncertainty_score":0.004487097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235378234239365,"score_gpt":0.2788900008613087,"score_spread":0.2665362185189151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}