{"id":"W4283761097","doi":"10.3390/molecules27134212","title":"The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Gilead Sciences","keywords":"Emtricitabine; Virology; Reverse transcriptase; Tenofovir alafenamide; Prodrug; Nucleoside; Pharmacology; Nucleoside Reverse Transcriptase Inhibitor; Medicine; Biology; Virus; RNA; Viral load; Biochemistry; Antiretroviral therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009442146,0.0002166682,0.0003045221,0.0001072342,0.0001177466,0.0002739574,0.0001747693,0.0002111182,0.001141255],"category_scores_gemma":[0.0001513642,0.000104964,0.0001649278,0.0001179172,0.00009154724,0.0001819836,0.00007552253,0.0002938916,0.0003279552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201773,"about_ca_system_score_gemma":0.0001926109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007996046,"about_ca_topic_score_gemma":0.001610215,"domain_scores_codex":[0.9998846,0.00002632455,0.00001079663,0.00001971313,0.00004396608,0.00001449858],"domain_scores_gemma":[0.9999435,0.00001289533,0.00001979307,0.000007790006,0.000008282041,0.000007751905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001523521,0.00002377297,0.0004347154,0.00007047026,0.00001146897,0.0000454102,0.00001096123,0.0007826879,0.993521,0.0001000964,0.00004442609,0.004802626],"study_design_scores_gemma":[0.00002991458,0.00085818,0.00283506,0.00001240551,0.00002237992,0.000420559,0.00002401967,0.002349355,0.9878535,0.00008975587,0.005497404,0.000007498364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853804,0.007627474,0.002443091,0.00007437472,0.00001781432,0.00003260763,0.0007241094,0.00005096352,0.00364909],"genre_scores_gemma":[0.9929137,0.002254557,0.002405607,0.00004515325,0.000005215097,0.00002390777,0.001103841,0.000009054744,0.001238919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141255,"threshold_uncertainty_score":0.003817856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344330075382998,"score_gpt":0.2498767722168966,"score_spread":0.2364334714630666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}