{"id":"W4283761097","doi":"10.3390/molecules27134212","title":"The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Gilead Sciences","keywords":"Emtricitabine; Virology; Reverse transcriptase; Tenofovir alafenamide; Prodrug; Nucleoside; Pharmacology; Nucleoside Reverse Transcriptase Inhibitor; Medicine; Biology; Virus; RNA; Viral load; Biochemistry; Antiretroviral therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434071,0.0001859663,0.0002433953,0.0001189214,0.0006558593,0.00003848979,0.0001073809,0.00002847757,0.00001946232],"category_scores_gemma":[0.00006991314,0.0001289668,0.00007323302,0.000299735,0.0001046189,0.00004244061,0.0002019044,0.0002133207,0.00003858476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002257574,"about_ca_system_score_gemma":0.00009194446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002979661,"about_ca_topic_score_gemma":0.00004770541,"domain_scores_codex":[0.9988229,0.00008071971,0.0002016466,0.0002915078,0.0003163162,0.0002869664],"domain_scores_gemma":[0.9994445,0.00009384259,0.00009738776,0.0002463852,0.00005200043,0.00006586458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002436886,0.002950885,0.2358571,0.0002400999,0.003783524,0.008614676,0.01390015,0.00008365101,0.2305689,0.008543368,0.3532096,0.1398113],"study_design_scores_gemma":[0.00912887,0.0009099663,0.3365034,0.0001615072,0.0006425265,0.0003395939,0.01467073,0.001369069,0.09069586,0.00201822,0.5424389,0.001121418],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766433,0.001186892,0.00001973569,0.0103599,0.00007543679,0.0003979532,0.00002451864,0.00007452594,0.01121772],"genre_scores_gemma":[0.9931676,0.0001650708,0.0003878083,0.001653615,0.00003295135,0.0001020591,0.00004228284,0.00003347192,0.004415189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1892293,"threshold_uncertainty_score":0.5259113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344330075382998,"score_gpt":0.2498767722168966,"score_spread":0.2364334714630666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}