{"id":"W4283761475","doi":"10.1002/1873-3468.14440","title":"Epigenetics of the frozen brain: roles for lysine methylation in hypometabolism","year":2022,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Histone; Epigenetics; Lysine; Methylation; Biology; Methyltransferase; Histone methyltransferase; Histone methylation; Histone H3; Gene expression; Transcription (linguistics); Cell biology; Biochemistry; Gene; DNA methylation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007958516,0.0001365076,0.0001370902,0.0001878069,0.0002299202,0.0002111581,0.0001340748,0.0001554222,0.001121769],"category_scores_gemma":[0.00008834469,0.00007096017,0.0001451129,0.000141442,0.0002571635,0.0002077416,0.0001678383,0.000198642,0.0001271308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001417628,"about_ca_system_score_gemma":0.0001145281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008423168,"about_ca_topic_score_gemma":0.002127152,"domain_scores_codex":[0.9999685,0.000003300974,0.000002249452,0.00001301276,0.00000612968,0.000006856972],"domain_scores_gemma":[0.9999198,0.000006143602,0.00003953508,0.000008164574,0.00001086616,0.0000154504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001674035,0.000008831918,0.0142947,0.00003690903,0.00001551495,0.00007660167,0.00009306128,0.00004136215,0.9818327,0.0001368596,0.00003747043,0.003258502],"study_design_scores_gemma":[0.000006197612,0.0002022605,0.7006203,0.00001433291,0.00004018997,0.0004999749,0.0002839631,0.0004689668,0.2958645,0.0003446061,0.001640211,0.00001446537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995828,0.001560383,0.001625221,0.00006874453,0.00001083425,0.000004691536,0.0002389277,0.00002101919,0.0006422141],"genre_scores_gemma":[0.9971269,0.0006015018,0.001016345,0.00004112418,0.000007626865,0.000007178196,0.0002291764,0.000006111958,0.0009641281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121769,"threshold_uncertainty_score":0.003752649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009839961079762677,"score_gpt":0.2400290636628892,"score_spread":0.2301891025831265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}