{"id":"W4283761475","doi":"10.1002/1873-3468.14440","title":"Epigenetics of the frozen brain: roles for lysine methylation in hypometabolism","year":2022,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Histone; Epigenetics; Lysine; Methylation; Biology; Methyltransferase; Histone methyltransferase; Histone methylation; Histone H3; Gene expression; Transcription (linguistics); Cell biology; Biochemistry; Gene; DNA methylation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003641943,0.0000875331,0.0001154754,0.0000637389,0.00009163356,0.000007164401,0.0002039244,0.00004273607,0.00001406273],"category_scores_gemma":[0.000115919,0.00007831801,0.000104154,0.0001722696,0.00003770684,0.000001875548,0.0001342422,0.00006984338,3.110604e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001636053,"about_ca_system_score_gemma":0.00002936732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002341128,"about_ca_topic_score_gemma":0.00004237599,"domain_scores_codex":[0.9991499,0.0001329675,0.0002226509,0.0001943229,0.0001529901,0.000147182],"domain_scores_gemma":[0.9995051,0.00003993868,0.0001281779,0.0002745926,0.00003287909,0.00001930154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003517131,0.00002901764,0.006822484,0.000007546602,0.00001668508,1.418683e-7,0.0001041556,0.01383298,0.9754528,0.00007587179,0.000822706,0.002800395],"study_design_scores_gemma":[0.0007919348,0.0001153201,0.0561019,0.000003567787,0.00002135296,5.503774e-7,0.00006468192,0.0004658647,0.8276339,0.0006414076,0.1140075,0.0001520356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876319,0.001688127,0.005129695,0.004866316,0.0002415161,0.0003052233,0.00005484273,0.000003015842,0.00007932351],"genre_scores_gemma":[0.9970541,0.00004690802,0.001085286,0.001338183,0.0001312606,0.00006908306,0.0001101334,0.00001811853,0.0001469014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.147819,"threshold_uncertainty_score":0.3193716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009839961079762677,"score_gpt":0.2400290636628892,"score_spread":0.2301891025831265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}