{"id":"W4283764858","doi":"10.1093/humrep/deac104.090","title":"O-076 Genomic and morphokinetic blueprint of mosaic embryos is evidence supporting their distinct clinical category","year":2022,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CReATe Fertility Centre; University of Toronto","funders":"","keywords":"Biology; Embryo; Comparative genomic hybridization; Aneuploidy; Blastomere; Embryo transfer; Genetics; Copy number analysis; Bioinformatics; Chromosome; Copy-number variation; Embryogenesis; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001265812,0.0001096433,0.0002675128,0.0000662312,0.0001940044,0.000009568633,0.00008809486,0.00003765979,0.0002631624],"category_scores_gemma":[0.001036394,0.0001016366,0.00008101222,0.0001093188,0.0001392102,0.00003916793,0.0002610225,0.0003286954,0.000006218499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005281653,"about_ca_system_score_gemma":0.00005573473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003048815,"about_ca_topic_score_gemma":0.000005575435,"domain_scores_codex":[0.9984064,0.0001158844,0.0005322693,0.0005744536,0.000207117,0.0001639013],"domain_scores_gemma":[0.9988,0.0001345128,0.0002794981,0.0006342346,0.00006653483,0.00008516276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004871253,0.0005365871,0.7945748,0.0004212303,0.0001227587,0.00007224661,0.002169256,0.0002646011,0.1355359,0.0003610493,0.004727317,0.06072716],"study_design_scores_gemma":[0.0005641517,0.0008187227,0.9814124,0.0001036056,0.0001350358,0.0003228642,0.0004921091,0.0004641289,0.01337551,0.0008353335,0.001328051,0.0001481256],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971659,0.001378468,0.00009053641,0.0005872934,0.0002193627,0.0002991925,0.00001179346,0.00006008573,0.000187343],"genre_scores_gemma":[0.9987098,0.000087174,0.0001858834,0.00009351272,0.0003456971,0.00002640632,0.0000425006,0.00001746123,0.0004915698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1868376,"threshold_uncertainty_score":0.4144621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0876745927603159,"score_gpt":0.3533481825556981,"score_spread":0.2656735897953821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}