{"id":"W4283766652","doi":"10.3390/v14071437","title":"HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant Gnidia sericocephala (Thymelaeaceae)","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; National Institutes of Health; New Partnership for Africa's Development; Department of Science and Technology, Ministry of Science and Technology, India; Department of Science and Technology, Republic of South Africa; Government of the United Kingdom; Department of Science and Innovation, South Africa; Alliance for Accelerating Excellence in Science in Africa; African Academy of Sciences; Canadian Institutes of Health Research; Philadelphia Foundation; Wellcome Trust; University of Pennsylvania","keywords":"Provirus; Peripheral blood mononuclear cell; Virology; Virus latency; Viral replication; Latency (audio); Virus; Entry inhibitor; In vitro; Biology; Human immunodeficiency virus (HIV); Pharmacology; Medicine; Viral entry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001764559,0.00008457705,0.0001353237,0.00005273488,0.0003745145,0.000009615737,0.00007898168,0.00003898978,0.0002079433],"category_scores_gemma":[0.00002913369,0.00005813241,0.00002007607,0.00007703165,0.0001790641,0.00005961833,0.00006050408,0.0001233429,0.00001726818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001941735,"about_ca_system_score_gemma":0.00003620159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007812905,"about_ca_topic_score_gemma":0.00002466058,"domain_scores_codex":[0.9992517,0.0002315794,0.0001467051,0.0001761192,0.00005832973,0.0001356049],"domain_scores_gemma":[0.9994929,0.0002453485,0.00008447389,0.0001393339,0.00001963399,0.00001824628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005781116,0.0002732075,0.4122262,0.00002456244,0.0002073879,0.00001874307,0.001632924,0.00002777806,0.5696731,0.0001915181,0.002316965,0.01282954],"study_design_scores_gemma":[0.002596567,0.0006059069,0.8782284,0.00006398577,0.0001285169,0.00004794039,0.001488984,0.0001286749,0.08662782,0.0001064623,0.02981493,0.0001618108],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98895,0.008918883,0.00009584222,0.0009712359,0.00009646511,0.0002024716,0.0006929044,0.00001591629,0.00005624992],"genre_scores_gemma":[0.9986377,0.0004865792,0.00009643877,0.0001320034,0.00001427517,0.00001896787,0.0005586596,0.000005881787,0.00004948839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4830452,"threshold_uncertainty_score":0.2880501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173240569814155,"score_gpt":0.240802224776053,"score_spread":0.2190698190779114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}