{"id":"W4283766652","doi":"10.3390/v14071437","title":"HPLC-Based Purification and Isolation of Potent Anti-HIV and Latency Reversing Daphnane Diterpenes from the Medicinal Plant Gnidia sericocephala (Thymelaeaceae)","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; National Institutes of Health; New Partnership for Africa's Development; Department of Science and Technology, Ministry of Science and Technology, India; Department of Science and Technology, Republic of South Africa; Government of the United Kingdom; Department of Science and Innovation, South Africa; Alliance for Accelerating Excellence in Science in Africa; African Academy of Sciences; Canadian Institutes of Health Research; Philadelphia Foundation; Wellcome Trust; University of Pennsylvania","keywords":"Provirus; Peripheral blood mononuclear cell; Virology; Virus latency; Viral replication; Latency (audio); Virus; Entry inhibitor; In vitro; Biology; Human immunodeficiency virus (HIV); Pharmacology; Medicine; Viral entry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001015479,0.0007123442,0.0002752663,0.000515543,0.0002308511,0.000176895,0.0001327759,0.000196346,0.001320964],"category_scores_gemma":[0.000154019,0.0001206399,0.0002226126,0.0005031427,0.000161051,0.0002080747,0.0002034559,0.0005420424,0.000616526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143999,"about_ca_system_score_gemma":0.0003422202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0010872,"about_ca_topic_score_gemma":0.002049369,"domain_scores_codex":[0.9999423,0.000007922827,0.000005047509,0.00001170652,0.00001573696,0.00001733959],"domain_scores_gemma":[0.9999442,0.00001724404,0.000007989965,0.0000043793,0.00001256783,0.00001370091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009590754,0.00007977911,0.0003572336,0.0001449522,0.00001851229,0.0001665101,0.00003581893,0.0002621248,0.9818074,0.00008948481,0.0001112173,0.01683118],"study_design_scores_gemma":[0.000075701,0.0008387256,0.007480875,0.00003259009,0.00005184997,0.0007653402,0.00009173511,0.001007844,0.9786429,0.0001313878,0.01086093,0.00002013705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9159975,0.01644403,0.04815472,0.0003710506,0.0001600671,0.001067732,0.003660981,0.0002536931,0.01389023],"genre_scores_gemma":[0.9528275,0.008642333,0.02575747,0.0003255658,0.00005959104,0.0001839924,0.003946553,0.00005090311,0.008206001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320964,"threshold_uncertainty_score":0.004419029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173240569814155,"score_gpt":0.240802224776053,"score_spread":0.2190698190779114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}