{"id":"W4283775335","doi":"10.1016/j.jmii.2022.06.002","title":"End-of-treatment HBsAg, HBcrAg and HBV RNA predict the risk of off-treatment ALT flares in chronic hepatitis B patients","year":2022,"lang":"en","type":"article","venue":"Journal of Microbiology Immunology and Infection","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Janssen Pharmaceuticals; Stichting voor Lever- en Maag-Darm Onderzoek; Fujirebio Europe; Gilead Sciences; Roche; Innogenetics; Bristol-Myers Squibb","keywords":"Medicine; HBsAg; Internal medicine; HBeAg; Hepatitis B; Chronic hepatitis; Gastroenterology; Multivariate analysis; Biomarker; Hepatitis B virus; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001236754,0.0003631295,0.0004600192,0.0004274904,0.0002228294,0.0005430176,0.0002744296,0.0006094185,0.001986658],"category_scores_gemma":[0.00264571,0.0002445679,0.0005165903,0.0003808819,0.0002386156,0.0004155461,0.0003008027,0.0005691322,0.0002463423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047936,"about_ca_system_score_gemma":0.0001737569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005408123,"about_ca_topic_score_gemma":0.0007094432,"domain_scores_codex":[0.9996156,0.0001829728,0.00004175824,0.00005763863,0.00004787875,0.00005417722],"domain_scores_gemma":[0.9970769,0.0008860977,0.001344461,0.000102248,0.0001415189,0.0004487596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001312361,0.00004458489,0.9966142,0.00001298083,0.00005605264,0.00001756325,0.00001209487,0.00005064214,0.0001169121,0.000004422774,0.00005291382,0.001705296],"study_design_scores_gemma":[0.0001040193,0.0005175921,0.9983062,0.0000121702,0.0000832794,0.000202116,0.00004309047,0.0005075783,0.00008474565,0.00003240515,0.0001030874,0.000003789581],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992811,0.0004085304,0.00004714555,0.00003697674,0.000003698773,0.000005957594,0.00007824626,0.000001854783,0.0001365593],"genre_scores_gemma":[0.9995579,0.00007804031,0.00006865609,0.00002437618,0.00001508647,0.000006161048,0.0001781219,0.00000110971,0.00007045958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001986658,"threshold_uncertainty_score":0.006646037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00800185342536035,"score_gpt":0.2387686807712912,"score_spread":0.2307668273459308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}