{"id":"W4283781182","doi":"10.3390/biom12070925","title":"The Multifaceted Role of the Ubiquitin Proteasome System in Pathogenesis and Diseases","year":2022,"lang":"en","type":"editorial","venue":"Biomolecules","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; York University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ubiquitin; Proteasome; Pathogenesis; Drug development; Computational biology; Biology; Protein degradation; Mechanism (biology); Deubiquitinating enzyme; Bioinformatics; Cell biology; Drug; Genetics; Immunology; Gene; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003894394,0.0003088203,0.0002973686,0.00005397444,0.0002856166,0.00005280832,0.0006903971,0.0003930804,0.000006952804],"category_scores_gemma":[0.0006079423,0.0002003364,0.0001850591,0.0001745006,0.0004073826,0.000002176967,0.0007827469,0.0002588255,0.000001440988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004796788,"about_ca_system_score_gemma":0.0003392692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001382355,"about_ca_topic_score_gemma":0.00009116358,"domain_scores_codex":[0.9977715,0.0005172032,0.000389783,0.0005177201,0.0004788099,0.0003249863],"domain_scores_gemma":[0.9986578,0.0001299104,0.0003240474,0.0007131496,0.0001045592,0.0000705796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004433186,0.0001503978,0.001103986,0.0007471215,0.0001757628,0.0000160571,0.0001798077,0.000007344538,0.9024029,0.0004112516,0.08543985,0.008922167],"study_design_scores_gemma":[0.000562658,0.0001775221,0.000562867,0.0001600869,0.00006168758,0.000005756278,0.0009121438,0.00002705675,0.2031972,0.00003765366,0.7939661,0.0003293083],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4897527,0.1346782,0.00003359059,0.0003077585,0.3563735,0.006394817,0.0112154,0.0001113385,0.001132781],"genre_scores_gemma":[0.8414367,0.002454463,0.0001208987,0.00004472304,0.1512685,0.002169497,0.001291541,0.0002101646,0.001003577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7085263,"threshold_uncertainty_score":0.8169479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004235278132979725,"score_gpt":0.2158281201977091,"score_spread":0.2115928420647294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}