{"id":"W4283782070","doi":"10.1038/s41467-022-31465-3","title":"Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; McGill University; Lunenfeld-Tanenbaum Research Institute; McGill University Health Centre","funders":"Government of Canada; Genentech; Government of Ontario; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Deutsches Krebsforschungszentrum; McGill University; U.S. Department of Defense","keywords":"Endocytic cycle; Endosome; Cell biology; Autophagy; ATG8; Retromer; Biology; Signal transducing adaptor protein; Transmembrane protein; Transport protein; Endocytosis; Signal transduction; Receptor; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502013,0.0003377285,0.0003069879,0.0002394795,0.0003298302,0.0005584238,0.0002162232,0.0003828736,0.001987467],"category_scores_gemma":[0.000108709,0.0001229734,0.0002344631,0.0002310581,0.0003239722,0.000301887,0.00040361,0.0005354676,0.001031895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008890858,"about_ca_system_score_gemma":0.0005337292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005385471,"about_ca_topic_score_gemma":0.0008489228,"domain_scores_codex":[0.9998461,0.00001987474,0.000007809233,0.00004129217,0.00004103719,0.00004381266],"domain_scores_gemma":[0.9999324,0.000007497389,0.00001581763,0.00001361837,0.00001427522,0.00001625931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001136631,0.00001598441,0.0006014598,0.0000724062,0.0000130493,0.0002229249,0.00001577816,0.0001213532,0.9931729,0.0009760459,0.0003865166,0.00428785],"study_design_scores_gemma":[0.000009457921,0.00005165966,0.003969906,0.00001266399,0.00001253585,0.001053359,0.00002543999,0.000992967,0.986298,0.0003532708,0.00721561,0.000005172904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518685,0.008375435,0.02227747,0.0007164132,0.0000952177,0.00008207699,0.001379352,0.0008344171,0.01437121],"genre_scores_gemma":[0.9877916,0.001958478,0.00476783,0.0001818088,0.00001481253,0.00004275504,0.0005625231,0.00004772021,0.004632435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987467,"threshold_uncertainty_score":0.006648719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02168212314294846,"score_gpt":0.3054825626739122,"score_spread":0.2838004395309637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}