{"id":"W4283784589","doi":"10.1016/j.biopsych.2022.06.029","title":"Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"H. Lundbeck A/S; Norges Forskningsråd; Helse Sør-Øst RHF; Universitetet i Bergen; Sunovion","keywords":"Neuroinflammation; Cell adhesion molecule; Peripheral; Intracellular; Mental illness; Cell adhesion; Intercellular adhesion molecule; Adhesion; Intercellular Adhesion Molecule-1; Neuroscience; Medicine; Inflammation; Cell biology; Psychology; Immunology; Chemistry; Psychiatry; Biology; Internal medicine; Mental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892654,0.0002514978,0.0001917186,0.0004404851,0.0001876379,0.0002338148,0.0001661568,0.0001906193,0.001670446],"category_scores_gemma":[0.0004661974,0.00006201411,0.000133959,0.0003316243,0.0002809654,0.0001620064,0.0003096847,0.0003073109,0.00006945067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000257452,"about_ca_system_score_gemma":0.0001595219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001827379,"about_ca_topic_score_gemma":0.003709686,"domain_scores_codex":[0.9999356,0.00001482723,0.000005725727,0.00001928863,0.00001267612,0.00001194631],"domain_scores_gemma":[0.9998469,0.00002753202,0.00007380729,0.000009041622,0.00001481617,0.00002794453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001699546,0.0001628033,0.8083858,0.0003210197,0.0001472741,0.0009134893,0.0006917068,0.0004560819,0.1441502,0.000413307,0.0004768147,0.04218196],"study_design_scores_gemma":[0.00002006117,0.000238467,0.9940453,0.00002495686,0.00005260331,0.0006807884,0.0002146298,0.0004676249,0.003586933,0.0003011324,0.0003620985,0.000005351515],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983343,0.0007588862,0.0002133388,0.0001012944,0.000004605121,0.000009505303,0.000142438,0.00000358265,0.0004320036],"genre_scores_gemma":[0.9990702,0.0002722854,0.0003940202,0.00004007327,0.00001012872,0.000008591287,0.0001207817,8.51963e-7,0.00008310591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001827379,"threshold_uncertainty_score":0.005588233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01029453126978276,"score_gpt":0.214676659032726,"score_spread":0.2043821277629432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}