{"id":"W4283785652","doi":"10.1021/acsnano.2c05391","title":"Single-File Translocation Dynamics of SDS-Denatured, Whole Proteins through Sub-5 nm Solid-State Nanopores","year":2022,"lang":"en","type":"article","venue":"ACS Nano","topic":"Nanopore and Nanochannel Transport Studies","field":"Engineering","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Azrieli Foundation","keywords":"Nanopore; Denaturation (fissile materials); Biophysics; Electrokinetic phenomena; Proteome; Chemistry; Nanotechnology; Intrinsically disordered proteins; Biomolecule; Biosensor; Molecule; Molecular dynamics; Materials science; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702955,0.0001575007,0.0002043375,0.0001311693,0.0002012084,0.000271104,0.0002254828,0.0002555078,0.0005062018],"category_scores_gemma":[0.0002982449,0.00007277878,0.0001594548,0.0001256706,0.0002492843,0.0004621948,0.0001380727,0.0003431639,0.0001552547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004423713,"about_ca_system_score_gemma":0.0001755627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009129982,"about_ca_topic_score_gemma":0.0008582126,"domain_scores_codex":[0.9999093,0.000005553199,0.000006555409,0.00002709105,0.00003049009,0.00002095555],"domain_scores_gemma":[0.9997908,0.00008905662,0.00004402652,0.00001371868,0.00003497163,0.00002746044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007406536,0.00002294295,0.0005595387,0.00002016532,0.000005108994,0.00004025946,0.00006052947,0.0003428081,0.9974183,0.0001453645,0.0000270047,0.001283942],"study_design_scores_gemma":[0.000004277783,0.000123335,0.005474356,0.000005092848,0.000006984218,0.00005768919,0.00009328593,0.01575808,0.9777831,0.0001243122,0.0005591837,0.00001027906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965689,0.0001256251,0.002885144,0.00002897642,0.00000660692,0.000006546652,0.0001250124,0.00004410273,0.0002089138],"genre_scores_gemma":[0.99537,0.0001991424,0.003646124,0.00001927255,0.000003035685,0.00001810933,0.0001853887,0.00001564401,0.0005432475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009129982,"threshold_uncertainty_score":0.003209651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009853158205888043,"score_gpt":0.2053112209375973,"score_spread":0.1954580627317093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}