{"id":"W4283785654","doi":"10.1007/s00401-022-02457-w","title":"Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Occupational Cancer Research Centre; University of Toronto","funders":"Australian Research Council; Medical Research Council; National Health and Medical Research Council; Centre of Excellence in Cognition and its Disorders, Australian Research Council; Macquarie University","keywords":"Neuroscience; Interneuron; Regulator; Biology; Disease; Alzheimer's disease; Amyloid (mycology); Premovement neuronal activity; Medicine; Gene; Pathology; Genetics; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001843932,0.000201379,0.0003098942,0.0001515595,0.0001495331,0.00001116378,0.0002069356,0.00002777752,0.0005556401],"category_scores_gemma":[0.0001453784,0.0001727512,0.0001634876,0.0004122148,0.0001760494,0.00008395189,0.0004300549,0.0004471875,0.00002546429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003861823,"about_ca_system_score_gemma":0.0001373956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009336321,"about_ca_topic_score_gemma":0.000001625401,"domain_scores_codex":[0.9977181,0.0005311965,0.0003129329,0.0004927487,0.0004960059,0.0004490466],"domain_scores_gemma":[0.9989362,0.0001454287,0.0001196244,0.0004385291,0.00004358252,0.0003166133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004369089,0.002811267,0.9706604,0.00003059892,0.0005071458,0.01529862,0.00009565089,0.0005135452,0.001148027,0.0002339823,0.002270366,0.00206129],"study_design_scores_gemma":[0.00157286,0.001691534,0.9935761,0.00002012183,0.0003582198,0.0001864438,0.00003619126,0.0002872581,0.00008325384,0.0002482324,0.001805146,0.0001346595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950678,0.001821,0.000004761845,0.001215382,0.0002319711,0.0005487914,0.00008168637,0.00007609813,0.0009524872],"genre_scores_gemma":[0.9986132,0.0002029149,0.00003889221,0.0007235862,0.0000862742,0.0001433435,0.0001110914,0.00003263053,0.00004807393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02291566,"threshold_uncertainty_score":0.7044588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03653796594460978,"score_gpt":0.2951311409495026,"score_spread":0.2585931750048928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}