{"id":"W4283792757","doi":"10.3389/fpubh.2022.915363","title":"Spike Mutation Profiles Associated With SARS-CoV-2 Breakthrough Infections in Delta Emerging and Predominant Time Periods in British Columbia, Canada","year":2022,"lang":"en","type":"article","venue":"Frontiers in Public Health","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University; BC Centre for Disease Control","funders":"Canadian Institutes of Health Research; British Columbia Centre for Disease Control; Genome British Columbia; Michael Smith Health Research BC; BCCDC Foundation for Public Health","keywords":"Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Mutation; Delta; Virology; Medicine; Biology; Genetics; Computer science; Outbreak; Internal medicine; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005871752,0.0005315315,0.0004422678,0.002157315,0.002264993,0.001228242,0.001419242,0.0004656041,0.001792971],"category_scores_gemma":[0.001621091,0.0003643283,0.0004034035,0.003833536,0.0007167161,0.0002192315,0.0009126694,0.0006465061,0.0002053005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01717822,"about_ca_system_score_gemma":0.01971796,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9910606,"about_ca_topic_score_gemma":0.9942701,"domain_scores_codex":[0.9991196,0.00006514539,0.00006133831,0.0001969648,0.0002333927,0.0003235437],"domain_scores_gemma":[0.9980506,0.000118642,0.00032215,0.00008032144,0.001025109,0.0004031375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007238796,0.00001715001,0.9964868,0.00001527347,0.00003258978,0.0001274286,0.0003712426,0.000101649,0.0003246181,0.0000334064,0.00037873,0.002038809],"study_design_scores_gemma":[0.000003724234,0.00002150626,0.9979568,0.00001500492,0.00001638313,0.0001271595,0.001161285,0.0003051252,0.00007821764,0.00001341691,0.0002938592,0.000007596105],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955142,0.000260366,0.0001426616,0.00006549033,0.000005524985,0.0000307972,0.003096411,0.00001222173,0.0008722059],"genre_scores_gemma":[0.9976153,0.00017272,0.00014586,0.00003677778,0.000001986893,0.00001241538,0.001460809,0.000005078623,0.0005489794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01717822,"threshold_uncertainty_score":0.1246373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029185328637968,"score_gpt":0.2947594137126535,"score_spread":0.2744675604262738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}