{"id":"W4283793980","doi":"10.3389/fcell.2022.938685","title":"Asymmetric Cell Division and Tumor Heterogeneity","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Chinese Academy of Sciences","keywords":"Cell division; Cancer stem cell; Biology; Asymmetric cell division; Carcinogenesis; Mitosis; Tumor progression; Stem cell; Cancer; Cell; Cancer cell; Cancer research; Tumor heterogeneity; Population; Cell biology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003313004,0.0005566115,0.0009051809,0.001840006,0.000267125,0.001101211,0.000590443,0.001073193,0.003106363],"category_scores_gemma":[0.0003817496,0.0002138996,0.00033475,0.001366494,0.00067238,0.00118632,0.0006997488,0.001495906,0.001958039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008366546,"about_ca_system_score_gemma":0.0007869923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047619,"about_ca_topic_score_gemma":0.001429681,"domain_scores_codex":[0.9998356,0.00002544597,0.00001682668,0.00003739855,0.00006321954,0.00002154825],"domain_scores_gemma":[0.9998565,0.00005887344,0.00002218565,0.000005445788,0.00003727456,0.00001973272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005430453,0.00003781188,0.0001819462,0.0106801,0.00004869479,0.0004060376,0.00008163248,0.0006101618,0.004127526,0.01780551,0.03609503,0.9298713],"study_design_scores_gemma":[0.000006942309,0.00004408125,0.0005091217,0.001111531,0.00002877886,0.001786373,0.00003687903,0.00008742067,0.0009265244,0.004654512,0.9907923,0.00001548481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001495614,0.9976124,0.0001805667,0.0002936583,0.0001478499,0.000003391743,0.00001561369,0.000007358789,0.001589554],"genre_scores_gemma":[0.001655348,0.996727,0.0001158947,0.0002113946,0.000167545,0.000006563739,0.00003575032,0.000001902527,0.001078589],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003106363,"threshold_uncertainty_score":0.01039177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03434754380255812,"score_gpt":0.2946145796569699,"score_spread":0.2602670358544118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}