{"id":"W4283793980","doi":"10.3389/fcell.2022.938685","title":"Asymmetric Cell Division and Tumor Heterogeneity","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Chinese Academy of Sciences","keywords":"Cell division; Cancer stem cell; Biology; Asymmetric cell division; Carcinogenesis; Mitosis; Tumor progression; Stem cell; Cancer; Cell; Cancer cell; Cancer research; Tumor heterogeneity; Population; Cell biology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002745468,0.0003654516,0.001517708,0.0005852564,0.00009835367,0.00001300537,0.0001013873,0.0001905328,0.0001443949],"category_scores_gemma":[0.00001927274,0.000288657,0.0001469897,0.0004480717,0.0001149907,0.00002251785,0.0003714063,0.0004127271,0.000008011232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002833772,"about_ca_system_score_gemma":0.0002685383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004568312,"about_ca_topic_score_gemma":0.000005396281,"domain_scores_codex":[0.9982817,0.0001322448,0.000483542,0.0006508708,0.000106491,0.0003451308],"domain_scores_gemma":[0.9994353,0.0000858848,0.0001646762,0.0001355782,0.000007726082,0.0001708047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000236273,0.00008921514,0.004307161,0.005197056,0.00005159846,0.00006420546,0.00003520253,1.13614e-8,0.000007455706,9.8484e-7,0.004415782,0.9858077],"study_design_scores_gemma":[0.0007715587,0.0001880579,0.0001406788,0.0003314279,0.0002030787,0.0001325377,0.0001048874,0.00000109593,0.00009787599,0.00001521025,0.9977129,0.0003006935],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001080142,0.9925293,0.00009095119,0.000006202619,0.0009478492,0.00059786,0.00008263291,0.00001547281,0.004649539],"genre_scores_gemma":[0.0002434225,0.989347,0.009150189,0.0001566258,0.00003831071,0.00008761104,0.0003718121,0.00003149812,0.0005735271],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9932971,"threshold_uncertainty_score":0.9999565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03434754380255812,"score_gpt":0.2946145796569699,"score_spread":0.2602670358544118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}