{"id":"W4283796350","doi":"10.1016/j.bone.2022.116485","title":"Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility","year":2022,"lang":"en","type":"review","venue":"Bone","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Office of Research and Development; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Pentosidine; Glycation; Advanced glycation end-product; Medicine; Bone fracture; Bone mineral; Internal medicine; Diabetes mellitus; Fragility; Bone healing; Osteoporosis; Endocrinology; Chemistry; Surgery; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155384,0.001163154,0.002209637,0.002947035,0.0002978085,0.001494944,0.001248492,0.001643283,0.004658443],"category_scores_gemma":[0.002462637,0.0002889225,0.0008110981,0.003419674,0.0006967139,0.001746086,0.001023429,0.00220397,0.001335679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008168754,"about_ca_system_score_gemma":0.002023688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001339594,"about_ca_topic_score_gemma":0.003083255,"domain_scores_codex":[0.9996442,0.00007800321,0.00006551944,0.00006107619,0.000120644,0.00003065509],"domain_scores_gemma":[0.9989936,0.0006227807,0.0001150034,0.00001808445,0.0001857574,0.00006473736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002382084,0.00005783234,0.0002431312,0.04373474,0.0002774634,0.0004469967,0.00006768989,0.0002534949,0.000939587,0.003589089,0.1331198,0.817032],"study_design_scores_gemma":[0.00005761666,0.0001086877,0.0009982863,0.01513533,0.00050793,0.001793076,0.00008672629,0.00008281448,0.0001708948,0.002691802,0.9783296,0.00003707339],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002419041,0.9988376,0.00004716757,0.0003652705,0.0005031579,0.000002619929,0.00001534246,0.00000260082,0.0002020116],"genre_scores_gemma":[0.0002419865,0.9982509,0.0001040341,0.000556855,0.0006520058,0.000004487369,0.00002232656,9.251347e-7,0.0001663844],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004658443,"threshold_uncertainty_score":0.01558399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05172911277611621,"score_gpt":0.3940473566196141,"score_spread":0.3423182438434979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}