{"id":"W4283798291","doi":"10.1016/s0140-6736(22)01054-6","title":"Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":450,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital de l'Enfant-Jésus; Centre hospitalier universitaire de Québec; Health and Social Services Centre University Institute of Geriatrics of Sherbrooke; Red Deer Regional Hospital; University of Manitoba; University of British Columbia; Centre Hospitalier Universitaire de Sherbrooke; Toronto Western Hospital; London Health Sciences Centre; University of Ottawa; Hamilton Health Sciences; University of Calgary; Health Sciences Centre; St. Michael's Hospital; Kelowna General Hospital; Sunnybrook Health Science Centre; McMaster University; University of Toronto; Western University; Medicine Hat Regional Hospital; Université de Sherbrooke; Queen's University; Centre Hospitalier de l’Université de Montréal; University of Saskatchewan; Queen Elizabeth II Health Sciences Centre; Grey Nuns Community Hospital; Fraser Health; University of Alberta","funders":"","keywords":"Medicine; Tenecteplase; Thrombolysis; Modified Rankin Scale; Fibrinolytic agent; Stroke (engine); Randomized controlled trial; Population; Bolus (digestion); Tissue plasminogen activator; Surgery; Internal medicine; Ischemic stroke; Myocardial infarction; Ischemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00124237,0.0003912266,0.002114702,0.00008822287,0.0003098539,0.00007997821,0.001079564,0.00004912823,0.0001843765],"category_scores_gemma":[0.0004517632,0.0002640496,0.00009202623,0.0002571307,0.000086472,0.00009329988,0.0005020447,0.000724696,0.000004374201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001211201,"about_ca_system_score_gemma":0.001977857,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1748495,"about_ca_topic_score_gemma":0.1956262,"domain_scores_codex":[0.9969196,0.000267395,0.0007943483,0.0005347304,0.0006770975,0.0008068389],"domain_scores_gemma":[0.9969344,0.0009833259,0.0005693897,0.001212069,0.0001054812,0.0001953887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8742479,0.0006769596,0.0009715771,0.0001331996,0.001546394,0.0005511323,0.0005084661,0.000505761,0.001016778,0.00003140227,0.1192562,0.0005542534],"study_design_scores_gemma":[0.944368,0.001193567,0.0002894103,0.00009741236,0.001372412,0.0001492849,0.001606971,0.02517663,0.0002267969,0.000008279718,0.02517902,0.000332228],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620606,0.0001508251,0.000676031,0.007493103,0.0005954051,0.0232353,0.001133513,0.00006104817,0.004594195],"genre_scores_gemma":[0.983365,0.00007053476,0.003865885,0.003439348,0.0006093016,0.006182732,0.0003759922,0.00007212673,0.002019068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09407714,"threshold_uncertainty_score":0.9999812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02408796206181624,"score_gpt":0.290235068060796,"score_spread":0.2661471059989798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}