{"id":"W4283806236","doi":"10.1128/jvi.01851-21","title":"Enhancement of CD4 Binding, Host Cell Entry, and Sensitivity to CD4bs Antibody Inhibition Conferred by a Natural but Rare Polymorphism in the HIV-1 Envelope","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Canada Foundation for Innovation; Canada Research Chairs","keywords":"Biology; Virus; Amino acid; Genetics; Polymorphism (computer science); Virology; Antibody; Population; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002317039,0.0001804867,0.0001959568,0.0001382213,0.0001057297,0.0003405672,0.0001479116,0.0002683613,0.00157901],"category_scores_gemma":[0.0002799389,0.0001198628,0.0001402956,0.00008144978,0.0001990003,0.0001735915,0.0001769745,0.0004115176,0.0002077606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002227821,"about_ca_system_score_gemma":0.0001350268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004432761,"about_ca_topic_score_gemma":0.0005580442,"domain_scores_codex":[0.9997252,0.00008878655,0.0000183671,0.00002827636,0.00005458131,0.00008486012],"domain_scores_gemma":[0.9998451,0.000048673,0.00002686133,0.00002124878,0.00001721025,0.00004096138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003695402,0.0001007996,0.001046447,0.00002500319,0.000008175037,0.00003705214,0.0000156013,0.00009153804,0.9962875,0.00009446413,0.00003019572,0.00189368],"study_design_scores_gemma":[0.00004538105,0.00362293,0.03004302,0.000009927168,0.00001935998,0.0006695736,0.00005252659,0.0009801778,0.9630488,0.0000780673,0.001422859,0.00000736113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982681,0.0004018834,0.0002769322,0.00002191925,0.000005752634,0.000009871417,0.00003311789,0.000008996002,0.0009734232],"genre_scores_gemma":[0.9990779,0.0001011478,0.0002359229,0.00002015641,0.000004661577,0.000006156146,0.0000645429,0.000002659239,0.0004867406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00157901,"threshold_uncertainty_score":0.005282342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007960951364669936,"score_gpt":0.2511280232493107,"score_spread":0.2431670718846408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}