{"id":"W4283809062","doi":"10.1016/j.ygyno.2022.06.017","title":"Olaparib treatment for platinum-sensitive relapsed ovarian cancer by BRCA mutation and homologous recombination deficiency status: Phase II LIGHT study primary analysis","year":2022,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Manitoba; CancerCare Manitoba","funders":"National Cancer Institute; Merck Sharp and Dohme; Memorial Sloan-Kettering Cancer Center; Merck; AstraZeneca","keywords":"Olaparib; Medicine; Homologous recombination; Ovarian cancer; Oncology; BRCA mutation; Cancer research; Mutation; Internal medicine; Cancer; Genetics; Poly ADP ribose polymerase; Gene; Biology; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001971366,0.001155523,0.001719859,0.0003122268,0.0002973177,0.001104843,0.0007420067,0.0008394163,0.004121026],"category_scores_gemma":[0.001099932,0.000634659,0.001499444,0.0003512254,0.0006465628,0.000596873,0.0003459479,0.002161952,0.0006502709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009789887,"about_ca_system_score_gemma":0.001898044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006363303,"about_ca_topic_score_gemma":0.001814447,"domain_scores_codex":[0.9993256,0.0003613547,0.00003685398,0.0001217727,0.00007430564,0.00008009324],"domain_scores_gemma":[0.9989159,0.0001877184,0.0003004266,0.0001113572,0.00009868496,0.0003858455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8399318,0.05308603,0.01412926,0.001177292,0.003422371,0.0001374152,0.0001608717,0.001619643,0.0274574,0.0002399154,0.004460667,0.05417734],"study_design_scores_gemma":[0.6776463,0.292871,0.01917419,0.00007147165,0.001815404,0.0002610042,0.00005904208,0.001163282,0.003459164,0.0002101757,0.003230996,0.00003788728],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872904,0.00245949,0.0008498601,0.0004993338,0.00007579973,0.003954624,0.002792548,0.0001017541,0.001976171],"genre_scores_gemma":[0.9874342,0.00145071,0.00137915,0.0009330609,0.0001646453,0.003817954,0.002776866,0.00003193517,0.0020115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004121026,"threshold_uncertainty_score":0.01378626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785850288555987,"score_gpt":0.3588367873183201,"score_spread":0.3309782844327602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}