{"id":"W4283809062","doi":"10.1016/j.ygyno.2022.06.017","title":"Olaparib treatment for platinum-sensitive relapsed ovarian cancer by BRCA mutation and homologous recombination deficiency status: Phase II LIGHT study primary analysis","year":2022,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of Manitoba; CancerCare Manitoba","funders":"National Cancer Institute; Merck Sharp and Dohme; Memorial Sloan-Kettering Cancer Center; Merck; AstraZeneca","keywords":"Olaparib; Medicine; Homologous recombination; Ovarian cancer; Oncology; BRCA mutation; Cancer research; Mutation; Internal medicine; Cancer; Genetics; Poly ADP ribose polymerase; Gene; Biology; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006945721,0.0002642754,0.0008354104,0.000422567,0.0008795561,0.00001461916,0.0000781218,0.0001727692,0.000903577],"category_scores_gemma":[0.0001641074,0.0002428927,0.0001495881,0.0007901409,0.0001091482,0.00008640582,0.0000807683,0.0002514439,0.000002678595],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00505959,"about_ca_system_score_gemma":0.0006284979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003269363,"about_ca_topic_score_gemma":0.000417047,"domain_scores_codex":[0.997376,0.0005844866,0.000577711,0.0007337675,0.0002577559,0.0004702831],"domain_scores_gemma":[0.9980912,0.0008414107,0.0004753607,0.0002621203,0.000190702,0.0001392164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02043008,0.08319217,0.05529848,0.0001223772,0.00863863,0.0016704,0.05736209,0.002534487,0.04457245,0.0008922403,0.02520795,0.7000787],"study_design_scores_gemma":[0.2321916,0.4533137,0.1311484,0.00002209413,0.0137709,0.0005522105,0.03139303,0.005682518,0.007440542,0.002952687,0.1199018,0.00163057],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988062,0.0007071079,0.0007356108,0.003717165,0.0005996893,0.003451593,0.0005644599,0.0001179167,0.002044471],"genre_scores_gemma":[0.990326,0.0002237571,0.0009693416,0.001506039,0.00005570361,0.004597013,0.001198989,0.00002492171,0.001098159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6984481,"threshold_uncertainty_score":0.9987598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785850288555987,"score_gpt":0.3588367873183201,"score_spread":0.3309782844327602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}