{"id":"W4283811192","doi":"10.3389/fcimb.2022.855119","title":"Miltefosine and Benznidazole Combination Improve Anti-Trypanosoma cruzi In Vitro and In Vivo Efficacy","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Agencia Nacional de Promoción Científica y Tecnológica; Universidad de Buenos Aires","keywords":"Benznidazole; Miltefosine; Trypanosoma cruzi; Parasitemia; In vivo; Amastigote; Pharmacology; In vitro; Chagas disease; Biology; Immunology; Leishmania; Leishmaniasis; Visceral leishmaniasis; Parasite hosting; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399432,0.0002957816,0.0004748989,0.0002510912,0.00006713416,0.0002099774,0.0001651084,0.0002281342,0.0009795355],"category_scores_gemma":[0.0001858385,0.00009979147,0.0001748143,0.0001036644,0.0001190041,0.0001804308,0.0001258087,0.000408688,0.0001698826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415692,"about_ca_system_score_gemma":0.000149929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599787,"about_ca_topic_score_gemma":0.001694394,"domain_scores_codex":[0.9998925,0.00002414497,0.00001085341,0.00001254954,0.00003013264,0.00002986196],"domain_scores_gemma":[0.9999268,0.00001532931,0.0000184242,0.000006216147,0.00001187947,0.00002129265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001087403,0.0002585027,0.000452258,0.0001192178,0.0000217756,0.00007364433,0.00002652248,0.0002480538,0.9841384,0.00005723007,0.0002131059,0.01330368],"study_design_scores_gemma":[0.0002479527,0.01858787,0.01595994,0.00003018448,0.0001678668,0.000654895,0.0000481394,0.001989072,0.9535168,0.00006572984,0.008717613,0.00001401903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903115,0.006609824,0.0007252859,0.0001484095,0.00006116324,0.00003139497,0.0001654475,0.0000584111,0.001888529],"genre_scores_gemma":[0.9949469,0.002293091,0.0008190498,0.00007035877,0.00003449808,0.00002010061,0.0003574352,0.000007350293,0.001451247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009795355,"threshold_uncertainty_score":0.003276885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00744873771995169,"score_gpt":0.2392057099764187,"score_spread":0.231756972256467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}