{"id":"W4283811506","doi":"10.1128/spectrum.01772-22","title":"Zika Virus Replication in a Mast Cell Model is Augmented by Dengue Virus Antibody-Dependent Enhancement and Features a Selective Immune Mediator Secretory Profile","year":2022,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Brock University; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"Antibody-dependent enhancement; Dengue virus; Virology; Zika virus; Biology; Dengue fever; Virus; Antibody; Flavivirus; Immune system; Original antigenic sin; Immunology; Influenza A virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002624955,0.0002611562,0.0004529564,0.0001558907,0.0001787258,0.00001345001,0.0001637434,0.0001257021,0.0009305921],"category_scores_gemma":[0.00001647555,0.0002543746,0.00009488189,0.0001872722,0.0000788004,0.00004039207,0.0001995107,0.0004634323,0.00002010837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004016408,"about_ca_system_score_gemma":0.0001916463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005416144,"about_ca_topic_score_gemma":0.000157099,"domain_scores_codex":[0.9980596,0.0001467831,0.0003752241,0.0008251482,0.0001199944,0.0004732045],"domain_scores_gemma":[0.9991326,0.00002801448,0.000186244,0.0005062961,0.00003583511,0.0001109642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009687136,0.000639774,0.001983473,0.00004362562,0.0001101379,0.00002725161,0.0006096178,0.00001062052,0.985453,0.00003822144,0.009855489,0.0002600484],"study_design_scores_gemma":[0.004667733,0.0008152357,0.004884134,0.00002315562,0.0001704276,0.00009955292,0.0004860131,0.002254283,0.9826666,0.0001017245,0.003488499,0.0003426492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839485,0.01104952,0.0002931859,0.00159368,0.0001299197,0.001399082,0.001189301,0.00005443036,0.0003423574],"genre_scores_gemma":[0.993105,0.0003747165,0.00009221482,0.001661154,0.00005684991,0.0005365559,0.001477585,0.00003479658,0.002661159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0106748,"threshold_uncertainty_score":0.9999908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003988166970946162,"score_gpt":0.2388518060733816,"score_spread":0.2348636391024354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}