{"id":"W4283814783","doi":"10.1139/bcb-2022-0027","title":"Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells","year":2022,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Liver physiology and pathology","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Shanghai University of Traditional Chinese Medicine; National Natural Science Foundation of China","keywords":"Sirius Red; Hepatic stellate cell; Hepatic fibrosis; Reactive oxygen species; Chemistry; Fibrosis; Carbon tetrachloride; Glutathione; GPX4; Lipid peroxidation; Internal medicine; Endocrinology; Glutathione peroxidase; Biochemistry; Oxidative stress; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570729,0.000179904,0.0003915106,0.00004095168,0.0001294309,0.0000022861,0.0001023928,0.0002115374,0.0001751668],"category_scores_gemma":[0.0000273141,0.000169974,0.00006697194,0.0001358533,0.0002303476,0.00001156826,0.0001315366,0.0002923975,0.000003131514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003030174,"about_ca_system_score_gemma":0.00006028968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009773368,"about_ca_topic_score_gemma":3.859949e-7,"domain_scores_codex":[0.9988433,0.0001480468,0.0002806535,0.000394934,0.00006625028,0.0002668753],"domain_scores_gemma":[0.9992644,0.0002266894,0.0001495287,0.0002213522,0.00004490811,0.00009309077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002721766,0.0001721272,0.00632966,0.0002552197,0.00004235396,0.00001398018,0.0003942505,0.000002324231,0.9914846,0.000004030245,0.0001737972,0.0008554984],"study_design_scores_gemma":[0.0007393081,0.001073992,0.0003841727,0.00001389954,0.00008890547,0.00003269995,0.0007662448,0.0001397197,0.9961627,0.00004842169,0.0003891971,0.0001607501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954299,0.003007761,0.00000316053,0.00005511194,0.000141368,0.0001391632,0.0001377546,0.0000228787,0.00106284],"genre_scores_gemma":[0.9987655,0.0001808841,0.0001651602,0.0001293666,0.0000418263,0.00002410965,0.0001950556,0.00001079288,0.0004873423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005945488,"threshold_uncertainty_score":0.6931337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188161952929346,"score_gpt":0.2323980808962411,"score_spread":0.2205164613669477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}