{"id":"W4283814834","doi":"10.1038/s41467-022-31443-9","title":"Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Monash Biomedicine Discovery Institute, Monash University; National Health and Medical Research Council; National Institutes of Health; Australian Synchrotron; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Australian Nuclear Science and Technology Organisation","keywords":"T-cell receptor; Cell biology; Receptor; CD3; T cell; Antigen; Epitope; Biology; Antigen-presenting cell; CD8; Chemistry; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002248303,0.0001090569,0.0001592666,0.000118662,0.000579968,0.000006408137,0.0005549703,0.000262458,0.004114338],"category_scores_gemma":[0.0001125092,0.0001159021,0.0001084046,0.0002569232,0.0001452244,0.0001068497,0.0003304667,0.001877434,0.0002748596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001317093,"about_ca_system_score_gemma":0.00005106898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006334797,"about_ca_topic_score_gemma":0.00001572223,"domain_scores_codex":[0.9987795,0.0005701196,0.0002860526,0.000169448,0.00005108794,0.0001437801],"domain_scores_gemma":[0.9984587,0.0003555572,0.0002338872,0.000787239,0.0001510227,0.00001355052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002407326,0.0006386891,0.0002624019,0.000004101995,0.0000696776,9.676921e-8,0.0004417405,0.000002411891,0.5125956,0.0006711572,0.4814817,0.003591642],"study_design_scores_gemma":[0.0004797612,0.0001645745,0.0006327075,0.000005847254,0.00003708221,0.00001514465,0.001209658,0.00001311371,0.1356369,0.00009154422,0.8615956,0.0001181216],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5987977,0.08926116,0.0006011759,0.01545103,0.03311575,0.002529954,0.00117015,0.001000205,0.2580729],"genre_scores_gemma":[0.9879928,0.0003435748,0.0002284974,0.0004361048,0.00001061264,0.00009952215,0.00356525,0.00001535186,0.007308336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3891951,"threshold_uncertainty_score":0.996796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540546781307134,"score_gpt":0.2538765111099232,"score_spread":0.2384710432968518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}