{"id":"W4283835426","doi":"10.1016/j.jconrel.2022.06.051","title":"Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy","year":2022,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"BC Cancer Agency; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; European Commission; Prostate Cancer Canada","keywords":"LNCaP; Prostate cancer; Gene knockdown; Androgen receptor; Cancer research; RNA interference; Gene silencing; Chemistry; Biology; Cancer; Cell culture; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514543,0.0002646879,0.0001771697,0.0001435409,0.0001289478,0.0002972321,0.0001783126,0.0003467551,0.0007374054],"category_scores_gemma":[0.0001047916,0.0001471865,0.0002041385,0.00009837688,0.0001868453,0.0002152763,0.0002527143,0.0005104029,0.0003629025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003375734,"about_ca_system_score_gemma":0.0001783187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004288645,"about_ca_topic_score_gemma":0.0007616971,"domain_scores_codex":[0.9999074,0.00001626358,0.000004925505,0.00001877547,0.0000327828,0.00001994369],"domain_scores_gemma":[0.9999663,0.000008030176,0.00001037786,0.000003434256,0.000006761125,0.000005076343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005002618,0.00001423014,0.00002422578,0.00004050467,0.0000065319,0.00003965807,0.00001461759,0.0002281731,0.9954182,0.0005321921,0.000139954,0.003491636],"study_design_scores_gemma":[0.00001612693,0.0001303607,0.0001256037,0.000004934881,0.00001697537,0.00009794124,0.00000908119,0.001445876,0.9931601,0.0001052126,0.004882026,0.000005818828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8962045,0.01027633,0.07917473,0.000961581,0.0003613395,0.000206951,0.0003730668,0.0005622766,0.01187916],"genre_scores_gemma":[0.9773943,0.002278802,0.01076429,0.0002101563,0.00002081395,0.00007547201,0.0001499245,0.00006736026,0.009038733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007374054,"threshold_uncertainty_score":0.002466857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090040039870836,"score_gpt":0.2639725106203746,"score_spread":0.2530721102216663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}