{"id":"W4283835426","doi":"10.1016/j.jconrel.2022.06.051","title":"Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy","year":2022,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"BC Cancer Agency; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institutes of Health Research; European Commission; Prostate Cancer Canada","keywords":"LNCaP; Prostate cancer; Gene knockdown; Androgen receptor; Cancer research; RNA interference; Gene silencing; Chemistry; Biology; Cancer; Cell culture; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003824811,0.0001092916,0.0002665096,0.00005958029,0.0001308094,0.00002490758,0.0002303287,0.00003406702,0.0001569341],"category_scores_gemma":[0.0001323922,0.00008463538,0.0002117513,0.00007312279,0.00001615996,0.000006774414,0.00004860857,0.00009167573,0.000003155509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002409605,"about_ca_system_score_gemma":0.0002451734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008589335,"about_ca_topic_score_gemma":0.000003270559,"domain_scores_codex":[0.9990116,0.0001013163,0.0003601901,0.0001540692,0.0001746146,0.000198202],"domain_scores_gemma":[0.9991655,0.00002806932,0.0002634094,0.0001379994,0.0002735943,0.0001313964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01792213,0.0001334536,0.0003221627,0.000004095448,0.0002063144,0.00000580645,0.0001470568,0.001678762,0.9457332,0.000005178968,0.01896349,0.01487834],"study_design_scores_gemma":[0.02365865,0.008468464,0.000286669,0.0000381826,0.00008975824,0.00006637045,0.0005936752,0.0003814873,0.7206119,0.00009355848,0.2453868,0.0003245232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925345,0.00476882,0.0001963507,0.001347543,0.0005395,0.0005090032,0.0000715763,0.000002746063,0.00003000491],"genre_scores_gemma":[0.9949657,0.001432673,0.0002233799,0.001466187,0.0004742478,0.000207794,0.00000554917,0.00001593148,0.001208572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2264233,"threshold_uncertainty_score":0.3451331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090040039870836,"score_gpt":0.2639725106203746,"score_spread":0.2530721102216663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}