{"id":"W4283835486","doi":"10.1016/j.neuron.2022.06.005","title":"A GPI-anchored Neurexin 3 proteoform mediates dendritic inhibition","year":2022,"lang":"en","type":"letter","venue":"Neuron","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; Health Sciences Centre","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neurexin; Inhibitory postsynaptic potential; Gene isoform; Synapse; Neuroscience; Cell biology; Alternative splicing; Chemistry; Biology; Postsynaptic potential; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003322253,0.0006812399,0.0005830847,0.0006252973,0.0009832444,0.0002785513,0.001474807,0.0004619236,0.002617772],"category_scores_gemma":[0.001354257,0.0006810961,0.0002913711,0.001330156,0.0006701905,0.0005028138,0.0009738377,0.007726852,0.0007683883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608479,"about_ca_system_score_gemma":0.0003175222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001066376,"about_ca_topic_score_gemma":0.000001253843,"domain_scores_codex":[0.991526,0.001636034,0.0006148008,0.002263959,0.002221352,0.001737823],"domain_scores_gemma":[0.9973778,0.001132714,0.0003222115,0.0008910796,0.00005897517,0.0002172706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005898941,0.0000765423,0.0000116221,0.00009584695,0.000001624555,0.01212568,0.00003147116,0.000005723395,0.4789969,0.00001188317,0.5083646,0.000219117],"study_design_scores_gemma":[0.0005467405,0.0008874044,0.0000477014,0.00001732587,0.00002918502,0.0008662342,0.000003641694,0.0001420645,0.3221706,0.0002211131,0.674602,0.0004658941],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2792969,0.00008433195,0.000003905027,0.7052004,0.00692803,0.003677411,0.0003942469,0.0008194385,0.003595315],"genre_scores_gemma":[0.05754282,0.0005026103,0.000004388839,0.9293352,0.002841496,0.001322871,0.00005242892,0.0002458261,0.008152367],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2241348,"threshold_uncertainty_score":0.9995641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05538089179592759,"score_gpt":0.3184724545307768,"score_spread":0.2630915627348492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}