{"id":"W4283836347","doi":"10.3390/pharmaceutics14071412","title":"Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Uppsala Universitet; Åhlén-stiftelsen; Science for Life Laboratory; Vetenskapsrådet; Magnus Bergvalls Stiftelse; Stiftelsen för Gamla Tjänarinnor; Knut och Alice Wallenbergs Stiftelse; Petrus och Augusta Hedlunds Stiftelse; Gun och Bertil Stohnes Stiftelse; Parkinsonfonden; Hjärnfonden; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Torsten Söderbergs Stiftelse","keywords":"In vivo; Antibody; Genetically modified mouse; Transferrin receptor; Immunotherapy; Ex vivo; Medicine; Pathology; Transgene; Microdialysis; Distribution (mathematics); Pharmacology; Immunology; Chemistry; Receptor; Biology; Internal medicine; Central nervous system; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002948253,0.001475234,0.0007070202,0.000991384,0.0003194133,0.0004049284,0.0005095864,0.001256812,0.001515965],"category_scores_gemma":[0.00008286552,0.0004809851,0.0005014815,0.0003661783,0.0005275126,0.000615976,0.0002726941,0.00202047,0.0004747653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004961459,"about_ca_system_score_gemma":0.0003620174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009447491,"about_ca_topic_score_gemma":0.001571367,"domain_scores_codex":[0.9997203,0.00002800672,0.00003045916,0.0001007035,0.00006124668,0.00005928678],"domain_scores_gemma":[0.9998515,0.00001192563,0.00005133088,0.00001471794,0.00001791199,0.00005263206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003713921,0.0002704655,0.00009625202,0.0000581073,0.00001305596,0.0000724452,0.00002576544,0.00008228726,0.9975677,0.00009943116,0.00009693868,0.001246286],"study_design_scores_gemma":[0.0001273466,0.003282895,0.001896977,0.00001812419,0.00006005231,0.000338749,0.00003615132,0.001373524,0.9901227,0.00009099611,0.002640313,0.00001197844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834008,0.002458832,0.008242283,0.0004550964,0.0001903997,0.0003058121,0.00153744,0.0006627188,0.002746684],"genre_scores_gemma":[0.962624,0.004367327,0.01222026,0.0003193007,0.00005535834,0.0007420078,0.002287758,0.000135293,0.01724874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515965,"threshold_uncertainty_score":0.005071402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1111276718815221,"score_gpt":0.3934213079814815,"score_spread":0.2822936360999594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}