{"id":"W4283837951","doi":"10.3390/cancers14143297","title":"Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Cancer immunotherapy; Medicine; Cancer; Hypoxia (environmental); Immunotherapy; Cancer research; Bench to bedside; Effector; Targeted therapy; Pharmacology; Immunology; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007838172,0.00008933433,0.00009978747,0.00003543104,0.00009003421,0.000005279047,0.0001018285,0.00004467732,0.0005731167],"category_scores_gemma":[0.00001820272,0.00009725018,0.00005580553,0.0001349886,0.00001877446,0.000002502174,0.00007657462,0.00009531991,0.000002030113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002609551,"about_ca_system_score_gemma":0.0003320293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001858128,"about_ca_topic_score_gemma":0.0003181383,"domain_scores_codex":[0.999286,0.00004671434,0.0001441112,0.0002434885,0.000126378,0.0001532828],"domain_scores_gemma":[0.9996439,0.00000660555,0.0000711645,0.0001747824,0.0000418626,0.00006171594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007503311,0.00000770178,0.0008093748,0.00000332898,0.00003699225,8.001589e-7,0.0001488452,0.004621597,0.9851443,0.00001366836,0.007813473,0.001324846],"study_design_scores_gemma":[0.0004725204,0.0003314975,0.001297982,0.000009629504,0.00002544858,9.452122e-7,0.0006240389,0.0002188519,0.9438684,0.00004681717,0.05291624,0.0001876512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962458,0.001853058,0.00008568996,0.0002253791,0.0005492821,0.0001285502,0.0001045035,0.000009906506,0.0007978023],"genre_scores_gemma":[0.9967451,0.00007590586,0.00005865832,0.002358337,0.0002177946,0.0001191987,0.0001541843,0.00001674011,0.0002540558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04510277,"threshold_uncertainty_score":0.6275226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494082188957031,"score_gpt":0.2575463597207561,"score_spread":0.2426055378311858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}