{"id":"W4283837951","doi":"10.3390/cancers14143297","title":"Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Cancer immunotherapy; Medicine; Cancer; Hypoxia (environmental); Immunotherapy; Cancer research; Bench to bedside; Effector; Targeted therapy; Pharmacology; Immunology; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004425023,0.0003927355,0.0004842927,0.0002480851,0.000242319,0.0008041307,0.0005845187,0.001501312,0.001512682],"category_scores_gemma":[0.0006021056,0.00009018024,0.0002623501,0.0002085497,0.0005392025,0.000791395,0.0003099053,0.002184478,0.0006886379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008575905,"about_ca_system_score_gemma":0.0006111446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005625456,"about_ca_topic_score_gemma":0.00269561,"domain_scores_codex":[0.9998102,0.00003951232,0.00001394653,0.00003104085,0.00008205176,0.00002339503],"domain_scores_gemma":[0.9998204,0.00005849479,0.00001831152,0.00000448078,0.00007085988,0.00002733982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003743993,0.00007403586,0.000325591,0.004718087,0.00008285671,0.001915995,0.0002091671,0.001172056,0.06184961,0.03360158,0.5873393,0.3083373],"study_design_scores_gemma":[0.00001650441,0.0001264807,0.000250879,0.0002801888,0.00002785599,0.001206355,0.00004683576,0.0002892875,0.007644512,0.002934471,0.9871638,0.00001279327],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004314396,0.8469037,0.005508831,0.07877766,0.05434164,0.0000373273,0.0001094901,0.000098401,0.009908462],"genre_scores_gemma":[0.02493343,0.8692774,0.002117062,0.03180366,0.04349373,0.00004761915,0.0001252252,0.0000468555,0.02815513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001512682,"threshold_uncertainty_score":0.006222308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494082188957031,"score_gpt":0.2575463597207561,"score_spread":0.2426055378311858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}