{"id":"W4284673687","doi":"10.3390/biomedicines10071602","title":"Telomere Dysfunction Is Associated with Altered DNA Organization in Trichoplein/Tchp/Mitostatin (TpMs) Depleted Cells","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"Medical Research Council; National Research Foundation; Università Degli Studi di Modena e Reggio Emila","keywords":"Telomere; Genome instability; Biology; Mitosis; Cell biology; Chromosome instability; Cancer research; Cell cycle; Cancer; Chromosome; Genetics; DNA damage; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003145362,0.00032612,0.0005853995,0.0008537889,0.0002576231,0.00002372389,0.000173446,0.000119018,0.001504675],"category_scores_gemma":[0.0003397938,0.0002703631,0.00004773455,0.005475932,0.0001262711,0.0001260252,0.00007568704,0.0003643621,0.00004145099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003934775,"about_ca_system_score_gemma":0.0003160033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004476894,"about_ca_topic_score_gemma":0.0001730688,"domain_scores_codex":[0.997289,0.0001696595,0.0005828844,0.0005865571,0.000887632,0.0004842599],"domain_scores_gemma":[0.9985895,0.0001635125,0.0002877724,0.0003948862,0.000355694,0.0002087052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000832721,0.001116884,0.449686,0.0001817331,0.0002265919,0.0004956741,0.003615513,0.00001446027,0.4736027,0.00002136011,0.06130872,0.008897685],"study_design_scores_gemma":[0.03150034,0.00563609,0.8094661,0.0007884094,0.0007706089,0.0005638329,0.01266905,0.001429278,0.09935764,0.00007249396,0.0361219,0.00162424],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941849,0.000276802,0.0001986335,0.003069841,0.0008132352,0.0007800395,0.0001134379,0.0002503837,0.0003127857],"genre_scores_gemma":[0.9945009,0.0001154995,0.0002072919,0.002134839,0.0002955815,0.00006536118,0.00103186,0.00008570146,0.001563005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.374245,"threshold_uncertainty_score":0.9999748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106638610906,"score_gpt":0.2180924930572232,"score_spread":0.2070261069481632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}