{"id":"W4284677444","doi":"10.1126/scisignal.abo1857","title":"The omega-3 hydroxy fatty acid 7( <i>S</i> )-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology","year":2022,"lang":"en","type":"article","venue":"Science Signaling","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ontario Institute for Cancer Research; York University; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Receptor; Peroxisome proliferator-activated receptor; Cell biology; Docosahexaenoic acid; Ligand (biochemistry); Biology; Biochemistry; Chemistry; Neuroscience; Fatty acid; Polyunsaturated fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001020251,0.0002980346,0.0002608752,0.0002159054,0.0002923027,0.0002457931,0.000188587,0.0003094203,0.001530369],"category_scores_gemma":[0.0001032929,0.0001172229,0.0003312177,0.0001810861,0.0002289869,0.0001472041,0.0001967923,0.000439665,0.0005402569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003758461,"about_ca_system_score_gemma":0.0002439145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008769592,"about_ca_topic_score_gemma":0.002082292,"domain_scores_codex":[0.9999087,0.00001358647,0.000006312406,0.00002887287,0.00002376065,0.0000188564],"domain_scores_gemma":[0.9999259,0.00001220111,0.00002393351,0.000008007796,0.00001451259,0.00001538548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008436839,0.000007281806,0.0002112011,0.00002458409,0.000006280183,0.00003634821,0.000006796069,0.00003014031,0.9978927,0.00008453124,0.00003022609,0.001585515],"study_design_scores_gemma":[0.000004892965,0.000126114,0.002039724,0.000006135701,0.00001333386,0.0002708499,0.00002710345,0.0002731023,0.9941242,0.00006192674,0.003045989,0.000006545138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675496,0.005835691,0.02071486,0.0003588906,0.0001078647,0.00005247603,0.001285299,0.0001508036,0.003944555],"genre_scores_gemma":[0.9755376,0.003951633,0.01359723,0.0002967444,0.00002926447,0.00004458628,0.001464264,0.00004221928,0.005036384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530369,"threshold_uncertainty_score":0.005119622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189930413776538,"score_gpt":0.2368859568752662,"score_spread":0.2249866527375008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}