{"id":"W4284689837","doi":"10.1126/science.abq0839","title":"Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":283,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institutes of Health; Public Health Agency of Canada; Wellcome Trust; Fred Hutchinson Cancer Research Center; University of Washington; Damon Runyon Cancer Research Foundation; Bill and Melinda Gates Foundation; Public Health Agency; George Mason University; California Institute of Technology; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Epitope; Virology; Immunization; Biology; Coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antibody; Neutralization; Immune system; Mosaic; Coronavirus disease 2019 (COVID-19); Virus; Immunology; Medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001017932,0.0001035803,0.0001532298,0.0002530645,0.0003735186,0.00004092856,0.0004524145,0.00002358882,0.00002676919],"category_scores_gemma":[0.0001556378,0.00009364074,0.00003801179,0.001262671,0.0004440383,0.0003338584,0.0004654388,0.000293497,0.00004207607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163233,"about_ca_system_score_gemma":0.0006286858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000239695,"about_ca_topic_score_gemma":0.00004969495,"domain_scores_codex":[0.9977476,0.00006326204,0.0001631592,0.0004645448,0.001029281,0.0005321503],"domain_scores_gemma":[0.9995039,0.00003763278,0.0000343769,0.0003049903,0.00005540527,0.00006375151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001894176,0.0002816268,0.007192983,0.0000242704,0.000003340124,0.0001102625,0.001102316,0.00005394422,0.9850865,0.0001936079,0.0002130056,0.005548736],"study_design_scores_gemma":[0.002740711,0.001804203,0.003618002,0.00005884878,0.00001218507,0.00003122551,0.003783423,0.05124285,0.8792939,0.001441879,0.05553707,0.0004356896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958299,0.0006541493,0.00001022091,0.0006507465,0.00005666924,0.0004964015,0.00001858218,0.00005493675,0.002228386],"genre_scores_gemma":[0.9912668,0.000008127504,0.00006145111,0.008450699,0.00002116239,0.000156919,7.39357e-7,0.000009965198,0.00002408063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1057926,"threshold_uncertainty_score":0.3818558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07934367473269921,"score_gpt":0.3473183756946266,"score_spread":0.2679747009619274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}