{"id":"W4284689837","doi":"10.1126/science.abq0839","title":"Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":283,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institutes of Health; Public Health Agency of Canada; Wellcome Trust; Fred Hutchinson Cancer Research Center; University of Washington; Damon Runyon Cancer Research Foundation; Bill and Melinda Gates Foundation; Public Health Agency; George Mason University; California Institute of Technology; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Epitope; Virology; Immunization; Biology; Coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antibody; Neutralization; Immune system; Mosaic; Coronavirus disease 2019 (COVID-19); Virus; Immunology; Medicine; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001651675,0.0003555337,0.0002269152,0.0002039708,0.0001166251,0.0001585119,0.000178738,0.0004774065,0.0005881159],"category_scores_gemma":[0.0001063566,0.0001142341,0.0001462407,0.00004617057,0.0001937169,0.000193491,0.0001211693,0.0003831963,0.00009633712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576181,"about_ca_system_score_gemma":0.0001932408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120733,"about_ca_topic_score_gemma":0.002441627,"domain_scores_codex":[0.9998916,0.00001481833,0.000004831556,0.00002453826,0.00002330034,0.00004083519],"domain_scores_gemma":[0.9999253,0.00001157815,0.00001988633,0.000008372293,0.00001326331,0.000021602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000281733,0.0001492377,0.0001802417,0.00003696023,0.000009060924,0.00002288824,0.00001757557,0.0002005256,0.9969876,0.00007794541,0.00006938574,0.001966945],"study_design_scores_gemma":[0.0001278766,0.009212311,0.00575599,0.00002468693,0.0000435033,0.0002062715,0.00008347724,0.003581627,0.9776844,0.0001724247,0.00309723,0.00001017589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950882,0.0006420664,0.00266402,0.0001190344,0.00004421019,0.00006352834,0.0001337677,0.00008848808,0.001156676],"genre_scores_gemma":[0.9957761,0.000342225,0.001991699,0.00008141979,0.000009489855,0.00005797673,0.0002001095,0.000009790144,0.001531202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120733,"threshold_uncertainty_score":0.002400637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07934367473269921,"score_gpt":0.3473183756946266,"score_spread":0.2679747009619274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}