{"id":"W4284694048","doi":"10.1124/jpet.122.001155","title":"Impact of SLC43A3/ENBT1 Expression and Function on 6-Mercaptopurine Transport and Cytotoxicity in Human Acute Lymphoblastic Leukemia Cells","year":2022,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Cytotoxicity; Lymphoblast; Cell culture; Pharmacology; Chemistry; Gene knockdown; Molecular biology; Mercaptopurine; In vitro; Medicine; Biochemistry; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003013434,0.0001757758,0.0004216584,0.0002753156,0.0001396868,0.000005323688,0.00007538068,0.0000839519,0.0002961284],"category_scores_gemma":[0.000001943492,0.0001381632,0.00008313135,0.0001232148,0.00022668,0.00009345038,0.00007581127,0.0004548544,2.842473e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008803896,"about_ca_system_score_gemma":0.0002914197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000226969,"about_ca_topic_score_gemma":3.88419e-7,"domain_scores_codex":[0.998722,0.0001429652,0.0004303091,0.0001783582,0.0003054225,0.0002209955],"domain_scores_gemma":[0.9994177,0.0001104513,0.000219237,0.00006699587,0.0000457887,0.0001398253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01002918,0.0006656796,0.007333868,0.00003171897,0.0003857744,0.0002214162,0.001209759,0.000234055,0.9794236,0.000009303059,0.0001838552,0.0002717177],"study_design_scores_gemma":[0.01643342,0.01214926,0.02983089,0.00004709389,0.0003251293,0.001101198,0.0007168804,0.001124373,0.937948,0.00004097648,0.000144341,0.0001383869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982246,0.001182726,0.00003311124,0.0000810529,0.0001634074,0.0002369758,0.00001596691,0.000005493202,0.00005666016],"genre_scores_gemma":[0.9988174,0.0004993845,0.00007413314,0.0004372426,0.00008296099,0.00001066802,0.000004284311,0.00001984709,0.00005402368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04147562,"threshold_uncertainty_score":0.5634132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02106962622488097,"score_gpt":0.3525066719827011,"score_spread":0.3314370457578201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}