{"id":"W4284695015","doi":"10.7554/elife.71854","title":"An entropic safety catch controls hepatitis C virus entry and antibody resistance","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Hepatitis C virus research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Wellcome; Medical Research Council; Wellcome Trust; Deutsche Forschungsgemeinschaft; World Health Organization","keywords":"Hypervariable region; Virus; Viral entry; Biology; Hepatitis C virus; Cell biology; Antibody; Virology; Genetics; Viral replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152539,0.0001909255,0.0002107878,0.0001183203,0.0001489657,0.0004125874,0.0002292244,0.0002368145,0.000917995],"category_scores_gemma":[0.0001685632,0.0001279732,0.0001123477,0.00005136613,0.0003800224,0.0001952585,0.0002350164,0.0003156457,0.0002174621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003070825,"about_ca_system_score_gemma":0.0001778262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003330517,"about_ca_topic_score_gemma":0.0004420174,"domain_scores_codex":[0.9998615,0.00001623807,0.0000074046,0.00002902944,0.00003212745,0.00005370641],"domain_scores_gemma":[0.9998797,0.00001815601,0.00004386552,0.00001443846,0.000009440419,0.0000344374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000192786,0.00003189452,0.0005317974,0.00001420216,0.000005158626,0.00004556291,0.0000168497,0.0003154388,0.9956632,0.0004311897,0.00004713237,0.002704827],"study_design_scores_gemma":[0.00004856594,0.000452758,0.009003725,0.000007001546,0.00001343183,0.0002618893,0.00006913469,0.004122461,0.9830297,0.0003920966,0.002586746,0.00001255176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969167,0.0004348015,0.001266866,0.00007035225,0.00001420256,0.000006537367,0.00003008884,0.00006381031,0.001196638],"genre_scores_gemma":[0.9984587,0.0001569965,0.0003448181,0.00002557879,0.000004531255,0.000003858602,0.00002638385,0.000009570372,0.0009694722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000917995,"threshold_uncertainty_score":0.00307101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134248098246506,"score_gpt":0.324236614796941,"score_spread":0.3108118049722904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}