{"id":"W4284697415","doi":"10.1172/jci.insight.159204","title":"Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; Centre Hospitalier Universitaire de Sherbrooke","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Institutes of Health; Bausch Health; American Diabetes Association; Novo Nordisk; American Heart Association; Pfizer","keywords":"Internal medicine; Lipogenesis; Nonalcoholic fatty liver disease; Endocrinology; Steatosis; Biology; Sterol regulatory element-binding protein; Cholesterol; Chemistry; Medicine; Lipid metabolism; Fatty liver; Disease; Sterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200955,0.0002057525,0.0005105512,0.0001893817,0.00008864589,0.00001197951,0.0001199464,0.00006578998,0.0007388412],"category_scores_gemma":[0.00001649274,0.0001534878,0.0001283173,0.0004570719,0.000038549,0.00009320652,0.0001275069,0.0002795107,0.00001174479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001203599,"about_ca_system_score_gemma":0.0001711993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000165117,"about_ca_topic_score_gemma":0.00004510991,"domain_scores_codex":[0.998543,0.0001076575,0.0002181772,0.0003517941,0.0005423398,0.0002370591],"domain_scores_gemma":[0.9992203,0.00004483176,0.0001276965,0.0004015869,0.00005948338,0.0001460826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006878896,0.005552243,0.9533679,0.0002570599,0.001093065,0.0005447755,0.01378707,0.00002952477,0.001100668,0.001281742,0.01947031,0.002827767],"study_design_scores_gemma":[0.006877894,0.0005299979,0.9277282,0.0001215319,0.0005073061,0.00006491772,0.0005469281,0.00001686735,0.01437505,0.0002157764,0.04878047,0.0002351048],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883502,0.005688465,0.000002869666,0.002424537,0.0001071093,0.0007664915,0.0003580192,0.00003041344,0.00227194],"genre_scores_gemma":[0.9962477,0.0001088989,0.000355049,0.00216594,0.0000790393,0.0002287053,0.0001331364,0.00002547032,0.0006560602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02931016,"threshold_uncertainty_score":0.8089793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218154049819894,"score_gpt":0.2384405266844274,"score_spread":0.2262589861862285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}