{"id":"W4284703131","doi":"10.3389/fimmu.2022.906352","title":"Dynamics of Melanoma-Associated Epitope-Specific CD8+ T Cells in the Blood Correlate With Clinical Outcome Under PD-1 Blockade","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"Medizinischen Fakultät, Eberhard Karls Universität Tübingen; Klaus Tschira Stiftung; European Research Council; H. Lundbeck A/S; Lundbeckfonden; Bristol-Myers Squibb; Carlsbergfondet; Eberhard Karls Universität Tübingen","keywords":"CD8; Blockade; Epitope; Melanoma; Flow cytometry; Cytotoxic T cell; Immunotherapy; Cancer research; T cell; Immune checkpoint; Biology; Immune system; Antigen; Immunology; Medicine; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001366216,0.0002347548,0.0003019523,0.0001544541,0.00007415582,0.000270739,0.00009268865,0.0001520516,0.0004364673],"category_scores_gemma":[0.0003726693,0.0001072323,0.0001677834,0.0001089288,0.00008578745,0.0001379888,0.0001235482,0.0002929025,0.00009916785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993283,"about_ca_system_score_gemma":0.000143629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007236563,"about_ca_topic_score_gemma":0.0004773442,"domain_scores_codex":[0.9999424,0.000009618657,0.000002988024,0.00002305425,0.000007880087,0.00001409748],"domain_scores_gemma":[0.9999005,0.00003558216,0.00003400915,0.000007899168,0.00000853424,0.00001354835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003138901,0.0004935131,0.3649036,0.0001185751,0.0002188974,0.0005054463,0.0002342944,0.1733225,0.4062393,0.0007249103,0.0006509386,0.04944914],"study_design_scores_gemma":[0.0000676981,0.00147619,0.208325,0.00001121186,0.0001445374,0.0005118512,0.0001006842,0.7432249,0.04421867,0.000897531,0.0009992763,0.00002247616],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974487,0.00008468837,0.002173177,0.00001654484,0.000002054493,0.000005645926,0.00008887148,0.00002388258,0.0001563298],"genre_scores_gemma":[0.999111,0.00004537505,0.0005230096,0.000006118743,0.000001995065,0.00001236919,0.0001317833,0.000002520318,0.0001657969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007236563,"threshold_uncertainty_score":0.001460075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190596029892993,"score_gpt":0.268901374262976,"score_spread":0.2498417712736767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}